18514-84-6

Basic information

• Product Name: 1H-CINNOLIN-4-ONE
• Synonyms: 1H-CINNOLIN-4-ONE;[1,8]NAPHTHYRIDIN-4-OL;4(1H)-Cinnolinone
• CAS NO: 18514-84-6
• Molecular Formula: C₈H₆N₂O
• Molecular Weight: 146.14604
• Mol File: 18514-84-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 303.5 °C at 760 mmHg
• Flash Point: 137.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 0.000928mmHg at 25°C
• Refractive Index: 1.666
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1H-CINNOLIN-4-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-CINNOLIN-4-ONE(18514-84-6)
• EPA Substance Registry System: 1H-CINNOLIN-4-ONE(18514-84-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 18514-84-6(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthesis, p. 288, 1987 DOI: 10.1055/s-1987-27921

InChI:InChI=1/C8H6N2O/c11-8-5-9-10-7-4-2-1-3-6(7)8/h1-5H,(H,10,11)

Upstream product

• 408508-53-2 4-phenoxy-cinnoline 
• 64-17-5 ethanol 
• 530-85-8 3-(2-nitrophenyl)-2-propynoic acid 
• 610-14-0 2-nitrobenzyl chloride 
• 134-20-3 2-carbomethoxyaniline 
• 111054-09-2 3-(2-Nitro-phenyl)-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-propionic acid tert-butyl ester 
• 111054-12-7 1-(2-nitrophenyl)-2-(triphenylphosphoranylidene)ethanone 
• 111054-05-8 1-(2-Amino-phenyl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone 
• 7647-01-0 hydrogenchloride 
• 109773-41-3 4-Oxo-3-triphenylphosphoranylidene-3,4-dihydrocinnoline 
• 551-93-9 2-aminoacetophenone 
• 16433-96-8 2-ethynyl-1-nitrobenzene 
• 119-61-9 benzophenone 
• 18514-85-7 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid 

Downstream Products

• 5152-84-1 4-chlorocinnoline 
• 1126475-27-1 1-(3-carboxy-4-fluorobenzyl)-4-oxo-1,4-dihydrocinnolin-1-ium chloride 
• 93334-81-7 1-Acetyl-4-cinnolon 
• 335242-55-2 3-bromo-1H-cinnolin-4-one 
• 1126475-25-9 methyl 2-fluoro-5-[(4-oxocinnolin-1(4H)-yl)methyl]benzoate 
• 1556-22-5 1-methylcinnolin-4(1H)-one 
• 4964-44-7 2-methylcinnolin-2-ium-4-olate 
• 854888-36-1 (6-nitro-cinnolin-4-yl)-phenyl-amine 
• 5265-43-0 1-Methyl-6-nitro-4-cinnolon 
• 7398-02-9 4-Methoxy-6-nitro-cinnolin 
• 68211-17-6 4-chloro-6-nitrocinnoline 
• 854897-28-2 6-amino-1H-cinnolin-4-one 
• 253-66-7 Cinnoline 
• 170646-73-8 3-(4-Oxo-4H-cinnolin-1-yl)-propionic acid methyl ester 

Relevant articles and documents

NOVEL CANNABINOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESS FOR THEIR PREPARATION

The present invention relates to compounds of f formula (I) as cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2 ) receptor modulators, and uses thereof f or treating diseases, conditions and/or disorders modulated by a cannabinoid receptor ( such as pain, neurodegenrative disorders, eating disorders, weight loss or control, and obesity).

A New Facile Synthesis of 4-Oxo-1,4-dihydrocinnolines

2-(2-Aminoaryl)-2-oxo-triphenylphosphoniumethylides 2a-d, readily available by standard procedures, are converted into 4-oxo-1,4-dihydrocinnolines 7a-d by treatment with nitrous acid and subsequent basic hydrolysis of the intermediate phosphoranes 6a-d.