- A mineralogically-inspired silver–bismuth hybrid material: Structure, stability and application for catalytic benzyl alcohol dehydrogenations under continuous flow conditions
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In the present contribution, we are reporting our findings on the structure, stability and synthetic applicability of a silver-containing hybrid material, which has recently been introduced by our research groups as a mineralogically-inspired novel heterogeneous catalyst. To determine how silver ions can be fixed into the structure of the catalyst, a set of experiments was designed with modification of the interlayer gallery under hydrothermal conditions. Subsequently, the stability of the material was examined in various solvents under demanding continuous flow conditions with the aim of achieving a clear picture of its applicability in organic syntheses. On the basis of the useful data obtained during the stability tests, a continuous flow methodology was developed for catalytic dehydrogenation of diversely substituted benzylic alcohols. As far as selectivity is concerned the catalyst performed superbly, while the conversions were varied from fair to extremely good.
- ?tv?s, Sándor B.,B?sz?rményi, éva,Fül?p, Ferenc,Kónya, Zoltán,Karádi, Krisztina,Kocsis, Marianna,Kukovecz, ákos,Mészáros, Rebeka,Pálinkó, István,Varga, Gábor
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- Combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid
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The invention discloses a combined production method for substituted benzaldehyde, substituted benzyl alcohol and substituted benzoic acid. The method comprises the following steps: (1) oxidation: a step of continuously introducing substituted toluene, a catalyst and oxygen-contained gas into an oxidation reactor and carrying out reaction so as to obtain oxidation reaction liquid; (2) hydrolyzation: a step of allowing the oxidation reaction liquid to continuously enter a hydrolysis reactor, and continuously adding water into the hydrolysis reactor and carrying out reaction so as to obtain a hydrolysis reaction mixture; (3) liquid-liquid layering: a step of layering the hydrolysis reaction mixture so as to obtain an oil phase and an aqueous phase; and (4) separation of products: a step of subjecting the oil phase to distillation so as to respectively obtain incompletely-reacted substituted toluene, substituted benzyl alcohol and substituted benzaldehyde, and subjecting the aqueous phase to cooling, crystallizing and filtering so as to obtain filtrate and substituted benzoic acid. The combined production method provided by the invention has the advantages of high raw material conversion rate, few by-products, good selectivity of target products, greenness and environmental protection.
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Paragraph 0079; 0080
(2017/01/31)
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- Selectivity Modulation of the Ley–Griffith TPAP Oxidation with N-Oxide Salts
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A wide variety of novel non-hygroscopic N-oxide tetraphenylborate salts were synthesized and evaluated as co-oxidants in the Ley–Griffith (TPAP) oxidation of benzylic and allylic alcohols under non-anhydrous conditions. The novel DABCOO·TPB (2:1) salt was herein unearthed as a viable competitor to the first-generation NMO·TPB (2:1) salt, but more importantly gave increased performance under oxidative competition. X-ray crystal structure analysis and NMR spectroscopy revealed that depending on the crystallization conditions 1:1, 2:1 or 3:2 N-oxide–tetraphenylborate salts could be formed.
- Moore, Peter W.,Jiao, Yanxiao,Mirzayans, Paul M.,Sheng, Lexter Ng Qi,Hooker, Jordan P.,Williams, Craig M.
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p. 3401 - 3407
(2016/07/26)
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- NMO·TPB: A selectivity variation on the Ley-Griffith TPAP oxidation
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A non-hygroscopic tetraphenylborate salt of N-methylmorpholine-N-oxide (NMO) is reported (NMO·TPB), which modulates the standard Ley-Griffith oxidation such that benzylic and allylic alcohols are oxidised selectively. An attractive feature of this new protocol is that anhydrous conditions are not required for this selective tetra-n-propylammonium perruthenate (TPAP) oxidation, superseding the requirement of molecular sieves.
- Moore, Peter W.,Mirzayans, Paul M.,Williams, Craig M.
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supporting information
p. 3567 - 3571
(2015/03/04)
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- KINASE INHIBITORS
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The present invention relates to compounds of Formula I or a pharmaceutically acceptable salt thereof, wherein variables R, Ar, X, and Ar1 and n are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.
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- OXAZOLE, OXADIAZOLE AND THIAZOLE DERIVATIVES AS DIACYLGLYCEROL ACYLTRANFERASE INHIBITORS
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The present invention relates to isoxazole, thiazole and oxidiazole derivatives, processes for their preparation, pharmaceutical compositions containing them and their use as medicaments, in particular to the use of these compounds in the prevention and treatment of diseases or disorders mediated by diacylglycerol acyltransferase (DGAT), particularly DGAT1.
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Page/Page column 117
(2010/04/06)
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- Reactions of 2-hydroxybenzophenones with Corey-Chaykovsky reagent
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A variety of 2-hydroxybenzophenones on reaction with Corey-Chaykovsky reagent underwent unprecedented rearrangements leading to 3-substituted benzofurans 8 and one-carbon homologated compounds 9 and 12. Compounds 9 could further be quantitatively transfor
- Chittimalla, Santhosh Kumar,Chang, Tsung-Che,Liu, Ting-Chun,Hsieh, Hsing-Pang,Liao, Chun-Chen
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p. 2586 - 2595
(2008/09/19)
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- PYRIMIDINYL-PYRAZOLE INHIBITORS OF AURORA KINASES
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The present invention provides a compound represented by Formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, or a combination thereof, wherein the substituents are as defined herein. The present invention also relates to a co
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Page/Page column 63-64
(2010/11/26)
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- Potassium channel openers
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Compounds having the formula I: are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.
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- Synthesis and structure-activity relationships of 2-(substituted phenyl)-3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidin-4-ones acting as H1-histamine antagonists
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2-(Substituted-phenyl)-3-[3-(N,N-dimethylamino)propyl]-1,3-thiazolidin-4-ones (1-15) showed dependence of the potency of the H1-histamine antagonism on the m- and p-substituents suggesting that the aromatic moiety binds the receptor by a strong
- Diurno, M. Vittoria,Mazzoni, Orazio,Correale, Gaetano,Gomez Monterrey, Isabel,Calignano, Antonio,La Rana, Giovanna,Bolognese, Adele
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p. 579 - 583
(2007/10/03)
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