- Preparation of some N-substituted hexahydro-4H-azepin-4-ones
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N-Substituted hexahydro-4H-azepin-4-ones were prepared from 2-cyclohexen-1-one via ozonolyse followed by reductive aminocyclization.
- Laronze,Dridi,Sapi
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p. 881 - 884
(2007/10/02)
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- HETEROCYCLIC ETHERS DERIVED FROM 6,11-DIHYDRODIBENZOTHIEPIN-11-OLS AND 4,9-DIHYDROTHIENO-2-BENZOTHIEPIN-4-OL; A NEW SERIES OF POTENTIAL ANTIDEPRESSANTS AND ANTIHISTAMINE AGENTS
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Reactions of 11-chloro-6,11-dihydrodibenzothiepin and methanesulfonates of 6,11-dihydrodibenzothiepin-11-ol (I), its 2-methyl derivative II and 4,9-dihydrothieno-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1-methylperhydroazepin-4-ol (XIX), and tropine gave the ethers V-X.Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and antihistamine activities of various degree.The most active compounds were the ethers V and VI.
- Polivka, Zdenek,Metys, Jan,Protiva, Miroslav
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p. 2034 - 2049
(2007/10/02)
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