1859-33-2

Usage

Uses

Used in Pharmaceutical Industry:
1-METHYLAZEPAN-4-ONE is used as a synthetic intermediate for the development of [application reason] N-Methyl-4-[1-(4-chlorophenyl)-1-phenylethoxy)hexahydroazepine (M295095), a compound with potential pharmaceutical applications.
Additionally, 1-METHYLAZEPAN-4-ONE is used as an impurity in the synthesis of [application type] Clemastine Fumarate (C568500) for [application reason] its role as an H1 histamine receptor antagonist and antihistaminic, which aids in the treatment of various allergic conditions.

InChI:InChI=1/C7H13NO/c1-8-5-2-3-7(9)4-6-8/h2-6H2,1H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 136259-04-6 3,3-ethylenedioxy-hexan-1,6-dial 
• 136259-05-7 8-Methyl-1,4-dioxa-8-aza-spiro[4.6]undecane 
• 1859-29-6 N-(2-Cyanoethyl)-N-(3-cyanopropyl)-methylamine 

Downstream Products

• 110406-94-5 C₁₄H₂₁N₃O 
• 79307-93-0 azelastine hydrochloride 
• 7546-66-9 3-Methyl-1,2,3,4,5,6-hexahydro-azepino<4,5-b>indol 
• 58581-89-8 azelastine 
• 740051-77-8 1-Acetyl-1-methyl-4-oxo-azepanium 
• 117078-69-0 2-Benzoyl-1-(hexahydro-1-methyl-1H-azepin-4-yl)hydrazin-hydrochlorid 
• 1859-26-3 acetic acid-(1-methyl-4-phenyl-hexahydro-azepin-4-yl ester) 

Relevant academic research and scientific papers

Preparation of some N-substituted hexahydro-4H-azepin-4-ones

N-Substituted hexahydro-4H-azepin-4-ones were prepared from 2-cyclohexen-1-one via ozonolyse followed by reductive aminocyclization.

HETEROCYCLIC ETHERS DERIVED FROM 6,11-DIHYDRODIBENZOTHIEPIN-11-OLS AND 4,9-DIHYDROTHIENO-2-BENZOTHIEPIN-4-OL; A NEW SERIES OF POTENTIAL ANTIDEPRESSANTS AND ANTIHISTAMINE AGENTS

Reactions of 11-chloro-6,11-dihydrodibenzothiepin and methanesulfonates of 6,11-dihydrodibenzothiepin-11-ol (I), its 2-methyl derivative II and 4,9-dihydrothieno-2-benzothiepin-4-ol (III) with 1-methylpiperidin-4-ol, 1-methylperhydroazepin-4-ol (XIX), and tropine gave the ethers V-X.Their methanesulfonates were pharmacologically tested and showed antireserpine, anticataleptic, and antihistamine activities of various degree.The most active compounds were the ethers V and VI.