Thieno[2.3-d]-4-pyrimidones: Synthesis, structure and pharmacological properties
The cyclization of 2-amino-3-carbethoxy or -carboxamido thophenes yields substituted or unsubstituted 4-pyrimidones. Their structure and their 'lactam-lactam' tautomerism have been investigated by i.r. spectroscopy. The eighteen compounds synthesized were tested for a few pharmacological activities. They have no anti-edema activity except for two. Ten of them have shown an analgesic activity equal or superior to that of acetyl salicylic acid.
Perrissin,Favre,Luu-Duc,et al.
p. 420 - 424
(2007/10/02)
Synthesis and Biological Activity of Tetrazolothienopyrimidines
4-Hydrazinothienopyrimidines (VI) undergo cyclization with nitrous acid to give tetrazolothienopyrimidines (VII).The latter compounds have been screened for their analgesic and antiinflammatory activities.
Shishoo, C. J.,Devani, M. B.,Karvekar, M. D.,Ullas, G. V.,Ananthan, S.,et al.
p. 666 - 668
(2007/10/02)
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