Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker that features a carboxylic acid at one end and a propargyl group at the other. This unique structure allows for versatile applications in chemical biology and medicinal chemistry. The carboxylic acid can react with primary amines to form stable amide bonds, while the propargyl group can react with azide-containing compounds to create a stable triazole linkage through click chemistry. The hydrophilic PEG linker enhances solubility in biological applications, making Propargyl-PEG2-acid a valuable tool for bioconjugation and the synthesis of small molecules, conjugates, and other compounds.
1859379-85-3
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Basic information
- Product Name: Propargyl-PEG2-acid
- Synonyms: Propargyl-PEG2-acid;Propyne-PEG1-CH2CH2COOH;3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid;Propargyl-PEG1-COOH
- CAS NO:1859379-85-3
- Molecular Formula: C8H12O4
- Molecular Weight: 172.18
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1859379-85-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C
- Solubility: N/A
- CAS DataBase Reference: Propargyl-PEG2-acid(CAS DataBase Reference)
- NIST Chemistry Reference: Propargyl-PEG2-acid(1859379-85-3)
- EPA Substance Registry System: Propargyl-PEG2-acid(1859379-85-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1859379-85-3(Hazardous Substances Data)
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1859379-85-3 Usage
Uses
Used in Chemical Biology and Medicinal Chemistry:Propargyl-PEG2-acid is used as a heterobifunctional crosslinker for the synthesis of small molecules, conjugates of small molecules and/or biomolecules, and other tool compounds. Its dual functional groups enable the formation of stable amide and triazole linkages, making it a versatile building block in chemical biology and medicinal chemistry.
Used in Bioconjugation:
Propargyl-PEG2-acid is used as a linker in bioconjugation, allowing for the stable attachment of biomolecules through the formation of amide bonds with primary amines and triazole linkages with azide-containing compounds.
Used in Drug Delivery Systems:
Propargyl-PEG2-acid can be used as a component in the development of drug delivery systems, such as antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation. Its hydrophilic PEG linker improves solubility and bioavailability, potentially enhancing the therapeutic outcomes of these systems.
Used in Targeted Protein Degradation:
Propargyl-PEG2-acid is used as a building block in the synthesis of proteolysis-targeting chimeras (PROTAC molecules) for targeted protein degradation. Its unique structure allows for the creation of molecules that can selectively degrade specific proteins, potentially leading to novel therapeutic strategies for various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1859379-85-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,5,9,3,7 and 9 respectively; the second part has 2 digits, 8 and 5 respectively.Calculate Digit Verification of CAS Registry Number 1859379-85:
(9*1)+(8*8)+(7*5)+(6*9)+(5*3)+(4*7)+(3*9)+(2*8)+(1*5)=253
253 % 10 = 3
So 1859379-85-3 is a valid CAS Registry Number.
1859379-85-3Upstream product
1859379-85-3Downstream Products
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Propargyl-PEG2-acid
