- Room-Temperature Palladium-Catalyzed Deuterogenolysis of Carbon Oxygen Bonds towards Deuterated Pharmaceuticals
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Site-specific incorporation of deuterium into drug molecules to study and improve their biological properties is crucial for drug discovery and development. Herein, we describe a palladium-catalyzed room-temperature deuterogenolysis of carbon–oxygen bonds
- Ou, Wei,Xiang, Xudong,Zou, Ru,Xu, Qing,Loh, Kian Ping,Su, Chenliang
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supporting information
p. 6357 - 6361
(2021/02/16)
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- Synthesis method of aryl deuterated methane
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The invention discloses a synthesis method of aryl deuterated methane, and relates to the technical field of organic synthesis. The synthesis method of aryl deuterated methane comprises the followingstep: reacting ketone with deuterium gas in the presence
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Paragraph 0065-0066; 0085-0090
(2020/06/15)
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- Photocatalytic transfer hydrogenolysis of aromatic ketones using alcohols
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A mild method of photocatalytic deoxygenation of aromatic ketones to alkyl arenes was developed, which utilized alcohols as green hydrogen donors. No hydrogen evolution during this transformation suggested a mechanism of direct hydrogen transfer from alcohols. Control experiments with additives indicated the role of acid in transfer hydrogenolysis, and catalyst characterization confirmed a larger number of Lewis acidic sites on the optimal Pd/TiO2 photocatalyst. Hence, a combination of hydrogen transfer sites and acidic sites may be responsible for efficient deoxygenation without additives. The photocatalyst showed reusability and achieved selective reduction in a variety of aromatic ketones.
- Gao, Zhuyan,Han, Jianyu,Hong, Feng,Lei, Lijun,Li, Hongji,Liu, Huifang,Luo, Nengchao,Wang, Feng
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p. 3802 - 3808
(2020/07/09)
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- The structure of ethylbenzene as a solute in liquid crystalline solvents via analysis of proton NMR spectra
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Previous attempts to analyze the proton spectrum of ethylbenzene as a solute in nematic liquid crystalline solvents failed, but a successful strategy has now been devised and is described here. The proton spectra of samples of ethylbenzene dissolved in four different liquid crystals have been analyzed to yield sets of the partially-averaged dipolar couplings, D(ij). The couplings are then used to test models for the structure and conformation of this molecule.
- Algieri,Castiglione,Celebre,De Luca,Longeri,Emsley
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p. 3405 - 3413
(2007/10/03)
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- Selective sp3 C-H bond activation of alkylaromatics promoted by platinum complexes
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Facile sp3 C-H bond activation of toluene, p-xylene and mesitylene, was photochemically promoted by trans-Pt(CH2CMe2Et)Br(PPh3)2 leading to trans-Pt(CH2Ar)Br(PPh3)2 quantitatively, while regioselective sp3 C-H bond cleavage at the benzylic position of ethylbenzene and cumene readily took place to yield styrene and α-methylstyrene, respectively.A possible reaction mechanism involving radical process is discussed on the basis of isotope and radical-trap experiments. Key words: Platinum; Benzyl; Bond activation; Radical; Photochemistry
- Miyashita, Akira,Hotta, Masatoshi,Saida, Yoshiko
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p. 353 - 358
(2007/10/02)
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- The Mechanism of Cyclisation of 1-Ethyl-2-nitrobenzene to give 3-Methylanthranil in Trifluoromethanesulfonic acid. Evidence for an Intramolecular Hydrogen Transfer
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Deuterium labelling has been used to show that the cyclisation in trifluoromethanesulfonic acid of 1-ethyl-2-nitrobenzene to 3-methylanthranil does not proceed through an equilibrium concentration of the aci-form of the substrate.Instead, the rate-determi
- Austin, Rupert P.,Ridd, John H.
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p. 1229 - 1232
(2007/10/02)
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- Side Chain Hydroxylation of Aromatic Hydrocarbons by Fungi. Part 2. Isotope Effects and Mechanism
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The benzylic hydroxylation of ethylbenzene, p-diethylbenzene, tetralin, indane, and toluene by the fungi Mortierella isabellina, Cunninghamella echinulata, and Helminthosporium species has been investigated by the use of deuterium-labelled substrates.An i
- Holland, Herbert L.,Brown, Frances M.,Munoz, Benito,Ninnis, Ronald W.
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p. 1557 - 1564
(2007/10/02)
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- Stereochemical Dynamics of Aliphatic Hydroxylation by Cytochrome P-450
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Previous studies on the stereochemistry of hydroxylation by cytochrome P-450 enzymes have been contradictory and confusing.Therefore, the hydroxylation of four isotopically substituted phenylethane substrates has been examined with a single isozyme of rabbit liver microsomal cytochrome P-450.In each case the corresponding 1-phenylethanol was essentially the only product.With ordinary phenylethane, the product was 48percent R-1-phenylethanol and 52percent the S isomer.With (R)-phenylethane-1-d, the product was 42percent R alcohol, while with (S)-phenylethane-1-d the product was 70percent R alcohol.When the substrate was phenylethane-1,1-d2, 50percent R alcohol was produced.The alcohols from the single-deuterium-substituted substrates were highly enriched in deuterium, indicating the operation of a large deuterium isotope effect on hydrogen removal.Most importantly, 23-40percent of the hydroxylation events resulted in alcohol with configuration opposite to that of the original hydrocarbon substrate.These "crossover" events require the intermediacy of a discrete tricoordinate carbon intermediate.These data unambiguously demonstrate that hydroxylation stereospecificity must be enforced by the surrounding protein tertiary structure and is not an inherent feature of the cytochrome P-450 reaction mechanism.
- White, Ronald E.,Miller, John P.,Favreau, Leonard V.,Bhattacharyya, Apares
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p. 6024 - 6031
(2007/10/02)
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