186320-14-9Relevant academic research and scientific papers
Maytansinoid derivatives with peptide linker and conjugates thereof
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Page/Page column 103; 104, (2016/04/20)
The invention relates to novel cell-binding agent-cytotoxic agent conjugate having a peptide linkers and more specifically to conjugates of formula (I). The invention also provides novel cytotoxic agents of formula (II), linker compounds represented by fo
Synthesis, biological evaluation, and docking studies of PAR2-AP-derived pseudopeptides as inhibitors of kallikrein 5 and 6
Severino, Beatrice,Fiorino, Ferdinando,Corvino, Angela,Caliendo, Giuseppe,Santagada, Vincenzo,Assis, Diego Magno,Oliveira, Juliana R.,Juliano, Luiz,Manganelli, Serena,Benfenati, Emilio,Frecentese, Francesco,Perissutti, Elisa,Juliano, Maria Aparecida
, p. 45 - 52 (2015/02/19)
A series of protease activated receptor 2 activating peptide (PAR2-AP) derivatives (1-15) were designed and synthesized. The obtained compounds were tested on a panel of human kallikreins (hKLK1, hKLK2, hKLK5, hKLK6, and hKLK7) and were found completely i
Preparation of 16β-estradiol derivative libraries as bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 using the multidetachable sulfamate linker
Berube, Marie,Delagoutte, Florian,Poirier, Donald
experimental part, p. 1590 - 1631 (2010/05/17)
Combinatorial chemistry is a powerful tool used to rapidly generate a large number of potentially biologically active compounds. In our goal to develop bisubstrate inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that interact with both th
beta-sheet mimetics and composition and methods relating thereto
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Page 23, (2010/11/30)
Compounds having the following structure: including pharmaceutically acceptable salts and stereoisomers thereof, wherein A, A′, B, X, Y, R2, R3, R4 and R5 are as defined herein. Such compounds have utility over
