- Catalytic asymmetric hydrogenation of pyrimidines
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The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
- Kuwano, Ryoichi,Hashiguchi, Yuta,Ikeda, Ryuhei,Ishizuka, Kentaro
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supporting information
p. 2393 - 2396
(2015/03/04)
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