18636-98-1 Usage
General Description
2-Methylbenzamidine hydrochloride is a chemical compound that consists of a benzamidine group with a methyl substituent and a hydrochloride salt. It is commonly used as a building block in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. As a strong base, it can also be used in the synthesis of various organic compounds. Additionally, 2-Methylbenzamidine hydrochloride has been studied for its potential antiviral and antitumor activities, making it a potentially important compound in medicinal chemistry research. Overall, this chemical compound has versatile uses in organic synthesis and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 18636-98-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,3 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18636-98:
(7*1)+(6*8)+(5*6)+(4*3)+(3*6)+(2*9)+(1*8)=141
141 % 10 = 1
So 18636-98-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2.ClH/c1-6-4-2-3-5-7(6)8(9)10;/h2-5H,1H3,(H3,9,10);1H
18636-98-1Relevant articles and documents
Catalytic asymmetric hydrogenation of pyrimidines
Kuwano, Ryoichi,Hashiguchi, Yuta,Ikeda, Ryuhei,Ishizuka, Kentaro
supporting information, p. 2393 - 2396 (2015/03/04)
The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
