18636-98-1 Usage
Uses
Used in Organic Synthesis:
2-Methylbenzamidine hydrochloride is used as a building block for the synthesis of various organic compounds, leveraging its strong basic nature to facilitate reactions and form new chemical entities.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Methylbenzamidine hydrochloride is utilized as a key component in the development of new drugs, capitalizing on its potential antiviral and antitumor activities to create novel therapeutic agents.
Used in Agrochemical Development:
2-Methylbenzamidine hydrochloride is employed in the agrochemical sector for the synthesis of compounds with pesticidal properties, contributing to the creation of effective solutions for crop protection and management.
Used in Medicinal Chemistry Research:
As a subject of study in medicinal chemistry, 2-Methylbenzamidine hydrochloride is used to explore its potential as a therapeutic agent, with ongoing research focused on understanding and harnessing its antiviral and antitumor capabilities for the advancement of medical treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 18636-98-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,6,3 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18636-98:
(7*1)+(6*8)+(5*6)+(4*3)+(3*6)+(2*9)+(1*8)=141
141 % 10 = 1
So 18636-98-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H10N2.ClH/c1-6-4-2-3-5-7(6)8(9)10;/h2-5H,1H3,(H3,9,10);1H
18636-98-1Relevant academic research and scientific papers
Catalytic asymmetric hydrogenation of pyrimidines
Kuwano, Ryoichi,Hashiguchi, Yuta,Ikeda, Ryuhei,Ishizuka, Kentaro
supporting information, p. 2393 - 2396 (2015/03/04)
The asymmetric hydrogenation of pyrimidines proceeded with high enantioselectivity (up to 99% ee) using an iridium catalyst composed of [IrCl(cod)]2, a ferrocene-containing chiral diphosphine ligand (Josiphos), iodine, and Yb(OTf)3 (cod=1,5-cyclooctadiene). The chiral catalyst converted various 4-substituted pyrimidines into chiral 1,4,5,6-tetrahydropyrimidines in high yield. The lanthanide triflate is crucial for achieving the high enantioselectivity as well as for activating the heteroarene substrate.
