186612-15-7Relevant articles and documents
Inhibitors of human histone deacetylase: Synthesis and enzyme assay of hydroxamates with piperazine linker
Chakrabarty, Shubhashis,Jasmine,Bhadaliya, Chetan,Sinha, Barij Nayan,Mahesh, Aruna,Bai, He,Blond, Sylvie Y.,Jayaprakash, Venkatesan
experimental part, p. 167 - 172 (2010/08/05)
The histone deacetylase (HDAC) enzyme plays an important role in gene transcription. Inhibitors of histone deacetylases induce cell differentiation and suppress cell proliferation in tumor cells. Hydroxamates with rigid linker have displayed better inhibi
Evaluation of some acylamide derivatives as potential hypoglycemic agents
Srivastava,Suresh,Pandeya,Pandey
, p. 452 - 457 (2007/10/03)
A series of new acylamide derivatives with piperidine, pyrrolidinyl and alanyl have been tested for their hypoglycemic activities. 2-(Pyrrolidinyl)-N-(3-chlorophenyl) acetamide and 2-(Piperazinyl)-N-(4-methoxy phenyl) acetamide were found to be the most a