- Preparation of highly enantiopure β-amino esters by Candida antarctica lipase A
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The enantioselectivities for the reactions of aliphatic β-substituted β-amino esters [RCH(NH2)CH2CO2Et with R = Me, Et, n-Pr, i-Pr, CHEt2, cyclohexyl and Ph] with butyl butanoate in neat butyl butanoate and with 2,2,2-trifluoroethyl butanoate in diisopropyl ether were studied in the presence of Candida antarctica lipase A. Enantioselectivities ranging from good (E = 70-100) to excellent (E>100) were commonly observed, allowing gram-scale resolution of the substrates.
- Gedey, Szilvia,Liljeblad, Arto,Lazar, Laszlo,Fueloep, Ferenc,Kanerva, Liisa T.
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p. 105 - 110
(2007/10/03)
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- Highly diastereoselective alkylation of perhydropyrimidin-4-ones directed toward the synthesis of α-substituted β-amino acids. 2
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The alkylation of several enantiomerically pure perhydropyrimidin-4-ones at C5 is described. For the methylation reaction, mixtures of 5,6-trans -and cis-disubstituted adducts were obtained with high diastereomeric ratios, whereas only the 5,6-
- Braschi,Cardillo,Tomasini,Venezia
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p. 7292 - 7298
(2007/10/02)
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