- A new series of selective COX-2 inhibitors: 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles
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A series of 5,6-diarylthiazolo[3,2-b][1,2,4]triazoles was prepared for evaluation of potency and selectivity against human COX-1 and COX-2 enzymes. This lead to the discovery of L-768,277, a potent and selective COX-2 inhibitor that also demonstrated good in vivo activity.
- Roy,Leblanc,Ball,Brideau,Chan,Chauret,Cromlish,Ethier,Gauthier,Gordon,Greig,Guay,Kargman,Lau,O'Neill,Silva,Therien,Van Staden,Wong,Xu,Prasit
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