- Copper-Mediated Direct Sulfenylation of 4-Hydroxyquinolinones and 4-Hydroxypyridones with Aryl Thiols via a C-H Functionalization Process
-
An efficient approach for the direct sulfanylation of 4-hydroxyquinolinones and 4-hydroxypyridones with aryl thiols in the presence of CuI/DMSO has been developed. The substrate scope is broad, allowing facile synthesis of a range of structurally diverse 3-sulfanyl-4-hydroxyquinolinones and 3-sulfanyl-4-hydroxypyridones in good efficiency.
- Guo, Tao,Wang, Hongyan
-
-
Read Online
- 3-Thioaryl-4-hydroxyquinolinone derivative and synthetic method thereof
-
The invention relates to quinolinone derivatives, in particular to a 3-thioaryl-4-hydroxyquinolinone derivative and a synthetic method thereof, and belongs to the field of organic chemistry. The 3-thioaryl-4-hydroxyquinolinone derivative is prepared by using 4-hydroxyquinolinone, sulfur powder and an iodobenzene derivative as raw materials, adding a ligand, an alkali source and a catalyst, and allowing reaction in a solvent. The sulfur source used herein is cheap and easy to obtain, has stable properties and is environmentally friendly; the synthetic method has mild conditions and is simple tooperate, low in cost and free of toxic and harmful effects. The 3-thioaryl-4-hydroxyquinolinone derivative has great application potential in the field of medicine. The invention provides a novel means to synthesize the 3-thioaryl-4-hydroxyquinolinone derivative.
- -
-
Paragraph 0018
(2018/03/25)
-
- Novel Method for Preparing 4-hydroxy-3-sulfanylcoumarin Derivatives or 4-hydroxy-3-sulfanylquinoline Derivatives and Their Compounds Made Thereby, and Its Use
-
The present invention relates to 4-hydroxy-3-sulfanylcoumarin derivatives represented by chemical formula 1, 4-hydroxy-3-sulfanylquinolinone derivatives represented by chemical formula 2, novel preparation methods thereof, and uses thereof. According to the present invention, the preparation methods can reduce the preparation cost by utilizing inexpensive catalysts, and at the same time, can yield desired products with high yield. In the chemical formula 1, R_1 to R_4 are as described in the present invention. In the chemical formula 2, R_5 to R_7 are as described in the present invention.COPYRIGHT KIPO 2018
- -
-
Paragraph 0097; 0109; 0110; 0145; 0146
(2018/10/16)
-
- Ammonium Iodide-Mediated Sulfenylation of 4-Hydroxycoumarins or 4-Hydroxyquinolinones with a Sulfonyl Chloride as a Sulfur Source
-
A novel ammonium iodide-induced sulfenylation of 4-hydroxycoumarins or 4-hydroxyquinolinones by using an aryl- or alkylsulfonyl chloride as the sulfur source gave a wide range of 3-sulfanyl-4-hydroxycoumarins or 3-sulfanyl-4-hydroxyquinolinones, respectiv
- Guo, Tao,Wei, Xu-Ning
-
supporting information
p. 2499 - 2504
(2017/10/06)
-
- Copper(I) Bromide-Dimethyl Sulfide-Catalyzed Direct Sulfanylation of 4-Hydroxycoumarins and 4-Hydroxyquinolinones with Arylsulfonylhydrazides and Selective Fluorescence Switch- On Sensing of Cadmium(II) Ion in Water
-
An efficient protocol for the direct sulfanylation of various 4-hydroxycoumarins and 4-hydroxyquinolinones in good yield with arylsulfonylhydrazides as sulfanylating agents was developed via copper(I) bromide?dimethyl sulfide-catalyzed S–O, S–N bond cleavage and C–S cross-coupling reactions. A highly selective fluorescence turning-on sensing of cadmium(II) ions in water using the synthesized 3-sulfanyl-4-hydroxycoumarin derivative was also investigated. (Figure presented.).
- Paul, Sanjay,Shrestha, Rajeev,Edison,Lee, Yong Rok,Kim, Sung Hong
-
supporting information
p. 3050 - 3056
(2016/10/09)
-
- Thermolytic ring closure reactions of 4-azido-3-phenylsulfanyl- and 4-azido-3-phenylsulfonyl-2-quinolones to 12H-quinolino-[3,4-b][1,4]benzothiazin-6(5H)-ones [1]
-
4-Hydroxy-3-phenylsulfanyl-2-quinolones 2 and 4-hydroxy-3-sulfonyl-2-quinolones 7, which are readily accessible from 4-hydroxy-2-quinolones 1 and diphenyldisulfide or thiophenol, can be converted to 4-azido-3-phenylsulfanyl-2-quinolones 10 or 4-azido-3-ph
- Taeubl, Anna E.,Langhans, Klaus,Kappe, Thomas,Stadlbauer, Wolfgang
-
p. 1259 - 1264
(2007/10/03)
-
- Sulfenylation of heterocyclic 1,3-dicarbonyl compounds
-
Anions of heteroaromatic 1,3-dicarbonyl compounds, such as 4-hydoxy-2-quinolones and 4-hydroxy-coumarins, react in DMF in the presence of potassium carbonate with diaryl disulfides to yield 3-arylsulfenyl derivatives. The arylthiolate anions formed in thi
- Schnell, Barbara,Kappe, Thomas
-
p. 1147 - 1157
(2007/10/03)
-