18694-10-5

Basic information

• Product Name: 3'-hydroxypapaverine
• Synonyms: 3'-hydroxypapaverine;3’-Demethyl Papaverine;5-[(6,7-DiMethoxy-1-isoquinolinyl)Methyl]-2-Methoxyphenol
• CAS NO: 18694-10-5
• Molecular Formula: C₁₉H₁₉NO₄
• Molecular Weight: 325.362
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics, Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 18694-10-5.mol

Chemical Properties

• Boiling Point: 506.5°Cat760mmHg
• Flash Point: 260.1°C
• Appearance: /
• Density: 1.22g/cm³
• CAS DataBase Reference: 3'-hydroxypapaverine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-hydroxypapaverine(18694-10-5)
• EPA Substance Registry System: 3'-hydroxypapaverine(18694-10-5)

Safety Data

• Hazardous Substances Data: 18694-10-5(Hazardous Substances Data)

Usage

Uses

A metabolite of Papaverine (P190500).

Upstream product

• 15248-39-2 6,7-dimethoxyisoquinoline 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 352238-75-6 (±)-(3-(benzyloxy)-4-methoxyphenyl)(6,7-dimethoxyisoquinolin-1-yl)methanol 
• 58-74-2 Papaverine 
• 4722-08-1 3,4-dimethoxy-β-methoxybenzeneethanamine 
• 54313-33-6 2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride 
• 169834-50-8 N-benzyl-(N-nor)-reticuline 
• 4781-58-2 (-)-Norreticuline 
• 13168-51-9 N-benzoyl-norreticuline 
• 186581-53-3 diazomethane 
• 57231-35-3 4',6-O,O-dimethylpapaveroline 
• 18694-11-6 N-(3'-Benzyloxy-4'-methoxyphenylacetyl)-β-methoxy-β-(3,4-dimethoxyphenyl)-ethylamin 

Relevant articles and documents

Biotransformation of papaverine and in silico docking studies of the metabolites on human phosphodiesterase 10a

The metabolism of papaverine, the opium benzylisoquinoline alkaloid, with Aspergillus niger NRRL 322, Beauveria bassiana NRRL 22864, Cunninghamella echinulate ATCC 18968 and Cunninghamella echinulate ATCC 1382 has resulted in O-demethylation, O-methylgluc

A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines

Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.