352238-75-6Relevant academic research and scientific papers
A divergent approach to benzylisoquinoline-type and oxoaporphine alkaloids via regioselective direct ring metalation of alkoxy isoquinolines
Melzer, Benedikt,Bracher, Franz
, p. 7664 - 7672 (2015/07/15)
Methoxy- and benzyloxy-substituted isoquinolines are regioselectively metalated at C-1 with the Knochel-Hauser base, subsequent trapping with aromatic aldehydes gives aryl(isoquinolin-1-yl)carbinols as building blocks for divergent syntheses of different types of benzylisoquinoline alkaloids. Photochemical cyclization of ortho-bromo analogues under reductive conditions gives oxoaporphine alkaloids. Nine benzylisoquinoline alkaloids and two oxoaporphine alkaloids were obtained in two or three steps from appropriate isoquinolines.
Synthesis of thalprzewalskiinone, a revision of structure
Al-Howiriny,Zemaitis,Gao,Hadden,Martin,Lin,Schiff Jr.
, p. 823 - 826 (2007/10/03)
A direct comparison of the spectral data for synthetic 2-methyl-6,7-dimethoxy-3′-methoxy-4′-hydroxyoxobenzylisoquinoline iodide (1) and its positional isomer 2-methyl-6,7-dimethoxy-3′-hydroxy-4′-methoxyoxobenzylisoquinoline iodide (2) with the data obtain
