18708-70-8

Basic information

• Product Name: 2,4,6-TRICHLORONITROBENZENE
• Synonyms: 1,3,5-trichloro-2-nitro-benzen;1-Nitro-2,4,6-trichlorobenzene;2,4,6-Trichloro-1-nitrobenzene;Benzene,1,3,5-trichloro-2-nitro-;1,3,5-TRICHLORO-2-NITROBENZENE;2,4,6-TRICHLORONITROBENZENE;2-Nitro-1,3,5-trichlorobenzene~2,4,6-Trichloronitrobenzene;2,4,6-TRICHLORONITROBENZENE OEKANAL,250
• CAS NO: 18708-70-8
• Molecular Formula: C₆H₂Cl₃NO₂
• Molecular Weight: 226.44
• EINECS: 242-518-1
• Product Categories: FINE Chemical & INTERMEDIATES;Nitro CompoundsVolatiles/ Semivolatiles;Alpha Sort;Analytical Standards;AromaticsChemical Class;Chemical Class;ChloroAnalytical Standards;Halogenated;TP - TZ;T-ZAlphabetic;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 18708-70-8.mol

Chemical Properties

• Melting Point: 70-72 °C
• Boiling Point: 303.2 °C at 760 mmHg
• Flash Point: 137.2 °C
• Appearance: yellow solid
• Density: 1.651 g/cm³
• Vapor Pressure: 0.0017mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: 2-8°C
• Solubility: methanol: 0.1 g/mL, clear
• Stability: Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
• BRN: 2213282
• CAS DataBase Reference: 2,4,6-TRICHLORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRICHLORONITROBENZENE(18708-70-8)
• EPA Substance Registry System: 2,4,6-TRICHLORONITROBENZENE(18708-70-8)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-33
• Safety Statements: 28-36/37/39-45
• RIDADR: UN 1578 6.1/PG 2
• WGK Germany: 3
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 18708-70-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,4,6-Trichloronitrobenzene is used as a building block for organic synthesis, serving as a key component in the creation of various organic compounds. Its unique structure and properties allow it to be a versatile precursor in the synthesis of a wide range of chemical products, including pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Chemical Intermediates:
In the chemical industry, 2,4,6-trichloro-nitrobenzene is utilized as an important intermediate for the production of various chemical compounds. Its role in the synthesis process is crucial for the development of end products that have specific applications in different sectors, such as dyes, plastics, and other industrial materials.
Used in Pharmaceutical Industry:
2,4,6-Trichloronitrobenzene is also employed in the pharmaceutical industry as a starting material for the synthesis of various drugs. Its chemical properties make it suitable for the development of active pharmaceutical ingredients, contributing to the creation of new medicines and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 2,4,6-trichloro-nitrobenzene is used as a key intermediate for the synthesis of agrochemicals, such as pesticides and herbicides. Its role in the production of these chemicals is essential for the development of effective solutions to protect crops and ensure agricultural productivity.
Overall, 2,4,6-trichloro-nitrobenzene is a versatile and essential compound in various industries, playing a significant role in the synthesis and production of a wide range of chemical products.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,4,6-TRICHLORONITROBENZENE is incompatible with strong bases and strong oxidizing agents.

Health Hazard

SYMPTOMS: Absorption of a similar chemical into the body leads to formation of methemoglobin which in sufficient concentration causes cyanosis.

Fire Hazard

Flash point data for 2,4,6-TRICHLORONITROBENZENE are not available; however, 2,4,6-TRICHLORONITROBENZENE is probably combustible.

InChI:InChI=1/C6H2Cl3NO2/c7-3-1-4(8)6(10(11)12)5(9)2-3/h1-2H

Upstream product

• 108-70-3 1,3,5-trichlorobenzene 
• 62406-71-7 2,4,6-trichloro-3-nitro-aniline 
• 7697-37-2 nitric acid 
• 99-09-2 3-nitro-aniline 
• 74087-85-7 3,3-dimethyldioxirane 
• 634-93-5 2,4,6-trichloroaniline 

Downstream Products

• 14227-18-0 1,3,5-trimethoxy-2-nitrobenzene 
• 74672-01-8 3,5-dichloro-2-nitroanisole 
• 83-21-6 5-chloro-1,3-dimethoxy-2-nitro-benzene 
• 857578-56-4 (3,5-dichloro-2-nitro-phenyl)-p-tolyl sulfide 
• 857578-95-1 5-chloro-2-nitro-1,3-bis-p-tolylsulfanyl-benzene 
• 860518-81-6 2-nitro-1,3,5-tris-p-tolylsulfanyl-benzene 
• 315-14-0 1,3,5-trifluoro-2-nitrobenzene 
• 1196-13-0 2,4,6-trichloronitrosobenzene 
• 84802-32-4 2,4,6-trichloronitrosobenzene dimer 
• 113864-61-2 2,6-diamino-4-chloro-nitrobenzene 
• 133387-40-3 4-(3,5-Dichloro-4-nitro-phenyl)-morpholine 
• 133387-37-8 2-morpholino-4,6-dichloro-1-nitrobenzene 
• 133387-42-5 C₁₄H₁₈ClN₃O₄ 
• 133387-44-7 C₁₄H₁₈ClN₃O₄ 

Relevant articles and documents

Zirconium-catalysed Oxidation of Primary Aromatic Amines to Nitro Compounds Using tert-Butylhydroperoxide

A broad range of primary aromatic amines (1a-x) with electron donating and accepting substituents are oxidized in good to excellent yields to the nitro compounds 3a-x using tert-butylhydroperoxide as the oxidant and Zr(OtBu)4 as the catalyst. The corresponding nitroso compounds 2m,-2n, 2s and 2u can be isolated in the conversion of electron-rich anilines 1m, 1n, 1s and 1u. The aminopyridines 5a-d are also converted to the corresponding nitropyridines 6a-d, but in lower yields (41-47%).

Ozone-mediated reaction of polychlorobenzenes and some related halogeno compounds with nitrogen dioxide: A novel non-acid methodology for the selective mononitration of moderately deactivated aromatic systems

In the presence of ozone and preferably methanesulfonic acid as catalyst, polychlorobenzenes undergo selective mononitration with nitrogen dioxide at low temperatures, giving the corresponding polychloronitrobenzenes, in most cases in nearly quantitative yields.

Oxidation of Primary Amines by Dimethyldioxirane

Dimethyldioxirane oxidizes primary amines rapidly, and generally in high yield, to the corresponding nitro compounds.The method can also be used to syntesize polynitro compounds.

FUNCTIONAL GROUP OXIDATION USING SODIUM PERBORATE

Sodium perborate in acetic acid is an effective reagent for the oxidation of anilines to nitroarenes and of sulphides to either sulphoxides or sulphones.It is also an excellent reagent for the oxidative deprotection of ketone dimethylhydrazones.Baeyer-Villiger oxidation of ketones can be carried out with sodium perborate in either trifluoroacetic acid or acetic acid/trifluoroacetic acid mixtures, and hydroquinones and certain highly substituted phenols are smoothly converted into quinones.

SODIUM PERBORATE - A CHEAP AND EFFECTIVE REAGENT FOR THE OXIDATION OF ANILINES AND SULPHIDES

Sodium perborate in acetic acid is an effective reagent for the oxidation of anilines to the corresponding nitroarenes; it is also highly effective for the oxidation of sulphides to either sulphoxides or sulphones.