187219-99-4

Basic information

• Product Name: AXOMADOL,6-DIMETHYLAMINOMETHYL-1-(3-METHOXY-PHENYL)-CYCLOHEXANE-1,3-DIOL
• Synonyms: AXOMADOL,6-DIMETHYLAMINOMETHYL-1-(3-METHOXY-PHENYL)-CYCLOHEXANE-1,3-DIOL;Axomadol;Unii-9J92U4cvs0;Nicosamide
• CAS NO: 187219-99-4
• Molecular Formula: C16H25NO3
• Molecular Weight: 279.3746
• Mol File: 187219-99-4.mol

Chemical Properties

• Boiling Point: 431.691°C at 760 mmHg
• Flash Point: 214.879°C
• Appearance: /
• Density: 1.125g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: AXOMADOL,6-DIMETHYLAMINOMETHYL-1-(3-METHOXY-PHENYL)-CYCLOHEXANE-1,3-DIOL(CAS DataBase Reference)
• NIST Chemistry Reference: AXOMADOL,6-DIMETHYLAMINOMETHYL-1-(3-METHOXY-PHENYL)-CYCLOHEXANE-1,3-DIOL(187219-99-4)
• EPA Substance Registry System: AXOMADOL,6-DIMETHYLAMINOMETHYL-1-(3-METHOXY-PHENYL)-CYCLOHEXANE-1,3-DIOL(187219-99-4)

Safety Data

• Hazardous Substances Data: 187219-99-4(Hazardous Substances Data)

Usage

Uses

Treatment of pain, central analgesic.

InChI:InChI=1/C16H25NO3/c1-17(2)11-13-7-8-14(18)10-16(13,19)12-5-4-6-15(9-12)20-3/h4-6,9,13-14,18-19H,7-8,10-11H2,1-3H3/t13-,14-,16+/m1/s1

Upstream product

• 108-22-5 Isopropenyl acetate 
• 105-38-4 vinyl propionate 
• 108-05-4 vinyl acetate 
• 1174221-52-3 rac-cis-[4-dimethylaminomethyl-3-hydroxy-3-(3-methoxy-phenyl)-cyclohexanone] 
• 187220-41-3 trans-4-dimethylaminomethyl-3-hydroxy-3-(3-methoxyphenyl)-cyclohexanone 

Relevant articles and documents

Crystalline Modifications of 6-Dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol

Crystalline modifications of (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol, (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol and mixtures thereof, pharmaceutical compositions and medicaments comprising

Process for Producing 6-Dimethylaminomethyl-phenyl-cyclohexane-1,3-diols

A process for producing 6-dimethylaminomethyl-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-1,3-diols from 6-dimethylaminomethyl-1-hydroxy-1-(3-hydroxy- or 3-C1-C4 alkoxyphenyl)-cyclohexane-3-ones by cataly

Process for Producing (1RS,3RS,6RS)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol

A process for producing (1R,3R,6R)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or (1S,3S,6S)-6-dimethylaminomethyl-1-(3-methoxyphenyl)-cyclohexane-1,3-diol or mixtures thereof.

PHOSPHATE SALTS OF 6-DIMETHYLAMINOMETHYL-L-(3-METHOXYPHENYL) -1,3-DIHYDROXYCYCLOHEXANE COMPOUNDS

The invention relates to 6-dimethylaminomethyl-l-(3- methoxyphenyl) -1,3-dihydroxycyclohexane compounds in the form of phosphate salts, to processes for preparing them and to the use of these compounds in pharmaceuticals.

Compositions and methods for the treatment of urinary incontinence

A pharmaceutical composition comprising an effective amount of a compound of formula I It has been surprisingly discovered that the composition of the present invention is effective for treating for the treatment of increased urinary urgency or urinary incontinence. Also disclosed are methods of treatment using said pharmaceutical compositions.

Combination of selected opioids with muscarine antagonists for treating urinary incontinence

Active compound combinations of compounds of group A, particularly opioids, and compounds of group B, particularly anti-muscarine agents and other substances suitable for treatment of an increased urge to urinate or urinary incontinence. Related pharmaceutical formulations and methods of treatment of an increased urge to urinate or urinary incontinence are also provided.

Enzymatic resolution of analgesics: δ-Hydroxytramadol, ε-hydroxytramadol and O-desmethyltramadol

Efficient enzymatic resolutions of the analgesic δ-hydroxytramadol rac-3 and ε-hydroxytramadol rac-4 have been achieved through pig liver esterase- and Candida rugosa lipase-catalyzed hydrolyses of the corresponding butyrates. The Candida rugosa lipase-catalyzed hydrolysis of O-desmethyltramadol butyrate rac-8a, having a remote aromatic acyloxy group as the only functional group amendable to a hydrolase-catalyzed reaction, proceeded with a good selectivity. Copyright (C) 2000 Elsevier Science Ltd.