Thiazole-containing polyether podands were prepared from the reactions of hydroxymethylthiazole derivatives with di-p-tosylates of corresponding tri, tetra, pentaethylene glycols in the presence of potassium hydride.
Kwon, Il-Chun,Koh, Young Kook,Choi, Jun-Hyeak,Kim, Hong-Seok
The photoredox-catalyzed hydrosulfamoylation of styrenes and its application in the novel synthesis of naratriptan
The hydrosulfamoylation of diverse aryl olefins provides facile access to alkylsulfonamides. Here we report a novel protocol utilizing radical-mediated addition and a thiol-assisted strategy to achieve the hydrosulfamoylation of diverse styrenes in modest to excellent yields under mild and economic reaction conditions. The methodology was found to provide an efficient and convenient approach for the synthesis of the anti-migraine drug naratriptan and it also can be used for the late-stage functionalization of natural products or medicines.