'Green' synthesis of important pharmaceutical building blocks: Enzymatic access to enantiomerically pure α-chloroalcohols
Thirty one recombinant ketoreductase enzymes were screened for the reduction of six α-chloroketones, the precursors of pharmaceutically valuable α-chloroalcohols. Several highly active and enantioselective ketoreductases were found and their applications
Zhu, Dunming,Mukherjee, Chandrani,Hua, Ling
p. 3275 - 3278
(2007/10/03)
A practical synthesis of optically active aromatic epoxides via asymmetric transfer hydrogenation of α-chlorinated ketones with chiral rhodium-diamine catalyst
A practical method for the synthesis of optically active aromatic epoxides has been developed via the formation of optically active α-chlorinated alcohols and intramolecular etherification. Optically active alcohols with up to 99% ee can be obtained from
Chemoenzymatic synthesis of (S) and (R)-propranolol and sotalol employing one-pot lipase resolution protocol
Synthesis of both enantiomers of biologically active propranolol and sotalol has been achieved in high optical purity by one-pot reduction of 3 and 7 followed by in situ lipase resolution of the respective chlorohydrins. Pseudomonas cepacia lipase immobilized on ceramic particles (PS-C) provided the chlorohydrin and acetate, which on nucleophilic substitution with isopropyl amine afforded the target amino alcohols in high enantioselectivity under mild reaction conditions.
Kamal, Ahmed,Sandbhor, Mahendra,Ali Shaik, Ahmad
p. 4581 - 4583
(2007/10/03)
PROCESS FOR PRODUCING OPTICALLY ACTIVE HALOHYDRIN COMPOUND
A process of preparing an optically active halohydrin compound characterized by comprising asymmetric hydrogen transfer reduction of an α-haloketone compound in the presence of a group 9 transition metal compound having a substituted or unsubstituted cyclopentadienyl group and an optically active diamine compound. The asymmetric hydrogen transfer reduction is preferably conducted in the presence of a base.
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(2008/06/13)
Practical synthesis of optically active styrene oxides via reductive transformation of 2-chloroacetophenones with chiral rhodium catalysts
(equation presented) A practical method for the synthesis of optically active styrene oxides has been developed via formation of optically active 2-chloro-1-phenylethanols generated by reductive transformation of ring-substituted 2-chloroacetophenones. Th
anti-Prelog microbial reduction of aryl α-halomethyl or α- hydroxymethyl ketones with Geotrichum sp. 38
Reduction of aryl α-halomethyl ketones 5a-d and 7a-h and α- hydroxymethyl ketones 10a-b by Geotrichum sp. 38 affording mostly the anti- Prelog alcohols was reported and the stereoselectivities of the reductive products were discussed.
Wei, Zhi-Liang,Li, Zu-Yi,Lin, Guo-Qiang
p. 13059 - 13072
(2007/10/03)
Biocatalytic synthesis of some chiral drug intermediates by oxidoreductases
Chiral intermediates were prepared by biocatalytic processes with oxidoreductases for the chemical synthesis of some pharmaceutical drug candidates. These include: (i) the microbial reduction of 1-(4-fluorophenyl)-4-[4-(5-fluoro-2-pyrimidinyl)-1 -piperazi
Patel,Hanson,Banerjee,Szarka
p. 1345 - 1360
(2007/10/03)
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