- A two step synthesis of BzR/GABAergic active flavones via a Wacker-related oxidation
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A general route for the synthesis of biologically important flavones is reported via a two step sequence employing a catalytic Wacker-Cook oxidation4b as the key step.
- Lorenz, Michael,Shahjahan Kabir,Cook, James M.
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experimental part
p. 1095 - 1098
(2010/04/05)
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- Efficient synthesis of nitroflavones by cyclodehydrogenation of 2prime;-hydroxychalcones and by the Baker-Venkataraman method
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Several nitroflavone derivatives were synthesized by cyclodehydrogenation of 2′-hydroxychalcones and by the Baker-Venkataraman approach, starting from 2′-hydroxyacetophenones and benzoic acid derivatives. Nitroflavones synthesised by the first synthetic a
- Barros, Ana I. R. N. A.,Silva, Artur M. S.
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p. 1505 - 1528
(2007/10/03)
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- Use of nitroflavonoids for the treatment of anxiety
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PCT No. PCT/GB96/02523 Sec. 371 Date Jul. 8, 1998 Sec. 102(e) Date Jul. 8, 1998 PCT Filed Oct. 16, 1996 PCT Pub. No. WO97/14414 PCT Pub. Date Apr. 24, 1997Methods of treating anxiety with flavonoid compounds according to Formula (I) and dimers thereof, co
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- Synthesis of halogenated/nitrated flavone derivatives and evaluation of their affinity for the central benzodiazepine receptor
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A series of halogenated/nitrated flavone compounds were synthesized. Some of the products were found to be potent central benzodiazepine receptor (BDZ-R) ligands. The structure-activity relationships (SAR) analysis of the new synthetic compounds, together with that of others already described, indicates that substitutions at position 6 or 6 and 3' in the flavone nucleus are the only ones that give rise to high affinity BDZ-R ligands.
- Marder, Mariel,Zinczuk, Juan,Colombo, Maria I.,Wasowski, Cristina,Viola, Haydee,Wolfman, Claudia,Medina, Jorge H.,Ruveda, Edmundo A.,Paladini, Alejandro C.
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p. 2003 - 2008
(2007/10/03)
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