- Sizing of amino acid based dendrimers in Langmuir monolayers
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The size and monolayer morphology of synthesised amphiphilic amino acid based dendrimers is studied in a Langmuir trough using Brewster Angle microscopy.
- Mulders, Suzanne J. E.,Brouwer, Arwin J.,Kimkes, Peter,Sudhoelter, Ernst J. R.,Liskamp, Rob M. J.
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- DENDRONIZED METALLIC OXIDE NANOPARTICLES, A PROCESS FOR PREPARING THE SAME AND THEIR USES
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The present invention relates to dendronized metallic oxide nanoparticles, a process for preparing the same and their uses.
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Page/Page column 90; 91; 97
(2015/11/30)
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- OPTICAL IMAGING PROBES
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The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject.
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Paragraph 0087; 0094; 0095
(2014/05/20)
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- Efficient synthesis of small-sized phosphonated dendrons: Potential organic coatings of iron oxide nanoparticles
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We report herein the synthesis of biocompatible small-sized phosphonated monomers and dendrons used as functional coatings of metal oxide nanoparticles, more specifically superparamagnetic iron oxides (SPIOs) for magnetic resonance imaging (MRI) and therapy through hyperthermia. The molecules were engineered to modulate their size, their hydrophilic and/or biocompatible character (poly(amido)amine versus oligoethyleneglycol), the number of anchoring phosphonate groups (monophosphonate versus phosphonic tweezers) and the number of peripheral functional groups for further grafting of dyes or specific vectors. Such a library of hydrophilic phosphonic acids opens new possibilities for the investigation of dendronized nanohybrids as theranostics.
- Garofalo, Antonio,Parat, Audrey,Bordeianu, Catalina,Ghobril, Cynthia,Kueny-Stotz, Marie,Walter, Aurlie,Jouhannaud, Julien,Begin-Colin, Sylvie,Felder-Flesch, Delphine
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supporting information
p. 5226 - 5239
(2014/12/10)
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- Highly specific, multi-branched fluorescent reporters for analysis of human neutrophil elastase
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Human neutrophil elastase (HNE) is a serine protease implicated in the pathogenesis of acute and chronic inflammatory disease. Here a series of, internally quenched, single fluorophore fluorescent reporters were synthesised that allowed the rapid, highly specific and sensitive analysis of HNE activity over closely related proteases. The Royal Society of Chemistry 2013.
- Avlonitis, Nicolaos,Debunne, Manuelle,Aslam, Tashfeen,McDonald, Neil,Haslett, Chris,Dhaliwal, Kevin,Bradley, Mark
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supporting information
p. 4414 - 4418
(2013/08/23)
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- Synthesis of bifunctional hydroxamic acids as novel ligands for the hydrophilic stabilization of iron oxide nanoparticles
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A general method for synthesizing bifunctional hydroxamic acids containing carboxylic acid or amino functionalities is reported. Various products from simple alkyl to complex dendrimer-like structures are described. Such molecules have recently been used in ligand-exchange reactions for the hydrophilic stabilization of originally oleic acid protected iron oxide nanoparticles. Georg Thieme Verlag Stuttgart · New York.
- Hofmann, Andreas,Graf, Christina,Kung, Shih-Hao,Kim, Myeongseob,Peng, Xiaogang,El-Aama, Randa,Ruehl, Eckart
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experimental part
p. 1150 - 1158
(2010/06/13)
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- Convergent synthesis and diversity of amino acid based dendrimers
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The synthesis of amino acid based dendrimers 25 (fifth generation, 32 endgroups), 30 (fourth generation, 81 endgroups), chiral dendrimer 23 (third generation, 8 endgroups) as well as core-modified dendrimers 34 and 38 by the convergent method is described. The amino acid building blocks are derived from hydroxybenzoic acid derivatives and amino alcohol derivatives, and access to a considerable molecular diversity of these novel dendrimers can be achieved, The synthesis can be carried out on a relatively large scale, and this easy access of the dendrimers may lead to many potential applications.
- Brouwer, Arwin J.,Mulders, Suzanne J. E.,Liskamp, Rob M. J.
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p. 1903 - 1915
(2007/10/03)
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- Synthesis of a novel amino acid based dendrimer
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An easy accessible dendrimer monomer 3,5-bis(2-tert-butyloxycarbonyl aminoethoxy) benzoic acid methyl ester 1 was designed. The monomer was converted to both the 'surface' and 'braching' monomer in a versatile synthesis of a novel amino acid based dendrimer by the covergent method, using the well established and high-yielding BOP-peptide coupling method.
- Mulders, Suzanne J.E.,Brouwer, Arwin J.,Van Der Meer, Peter G.J.,Liskamp, Rob M.J.
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p. 631 - 634
(2007/10/03)
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