cas 187975-62-8, (S)-4-(4-Hydrazinylbenzyl)-2-oxazolidinone | Articles data ｜lookchem

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187975-62-8

Articles about 187975-62-8Total 6 be found

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Convenient and industrially viable process for preparation of zolmitriptan
The present invention provides a convenient and industrially viable process for preparation of zolmitriptan. The invention specifically relates to a method for obtaining (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride of desired purity by separation and isolation in a particular pH range to give higher yield and purity.
Neelakandan,Manikandan,Santosha,Prabhakaran
p. E332-E334
(2014/11/07)

PROCESS FOR PREPARATION OF ZOLMITRIPTAN
The present invention provides a convenient and industrially viable process for preparation of Zolmitriptan (I) having desired purity. The invention specifically relates to a method for isolating (S)-4-(4-hydrazinobenzyl)-1,3-oxazolidin-2-one hydrochloride (IIIa) of desired purity by separating the undesired inorganic side products such as stannous hydroxide by manipulation of pH at different stages and finally treating with N,N-dimethylamino butyraldehyde diethyl acetal in an acidic medium to provide Zolmitriptan (I) conforming to regulatory specifications.
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Page/Page column 0030

(2014/08/19)

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF
The present invention relates to an improved process for the preparation of the active pharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.
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Page/Page column 11

(2011/05/16)

PROCESS FOR THE PREPARATION OF ZOLMITRIPTAN, SALTS AND SOLVATES THEREOF
The present invention relates to an improved process for the preparation of the activepharmaceutical ingredient zolmitriptan. In particular, it relates to an efficient process for the preparation of zolmitriptan and its pharmaceutically acceptable salts and solvates.
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Page/Page column 17; 21-22

(2009/05/29)

N-Desmethyltriptans: One pot efficient synthesis of N-methyl-2-5- [substituted- 1H- indole-3-yl]ethanamines
A straightforward and highly improved method to synthesize N-methyl-2-[5-[substituted-lH-indole-3-yl]ethanamines 4-6, which are the metabolites of tryptans 1-3, is reported. The significance of the process is its simplicity and efficiency in isolating the N- desmethyltriptans derivatives as a free base.
Mittapelli, Vasantha,Ray, Puma Chandra,Chauhan, Yogendra Kumar,Datta, Debashish
experimental part
p. 590 - 594
(2010/01/06)

CONVERSION OF AROMATIC DIAZONIUM SALT TO ARYL HYDRAZINE
The present invention relates to the preparation of aryl hydrazines and their salts by treating aryl diazonium salts with triphenyl phosphine followed by hydrolysis of the resulting triphenyl-aryl hydrazyl phosphonium salt to get aryl hydrazine or its sal
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Page/Page column 6

(2008/06/13)

More Articles about upstream products of 187975-62-8

152305-23-2
(S)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one

More Articles about downstream products of 187975-62-8

Chemical Properties

Boiling Point: 519.346°C at 760 mmHg
Flash Point:267.891°C
Density: 1.318g/cm³
Solubility:Dimethylformamide
Storage Temp.:Refrigerator
Vapor Pressure: 0mmHg at 25°C
PSA: 76.38000
LogP: 1.72520

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