188252-74-6

Basic information

• Product Name: 4-methyl-N-[[(4-methylbenzoyl)amino](phenyl)methyl]benzamide
• Synonyms: 4-methyl-N-[[(4-methylbenzoyl)amino](phenyl)methyl]benzamide
• CAS NO: 188252-74-6
• Molecular Formula: C₂₃H₂₂N₂O₂
• Molecular Weight: 358.43298
• Mol File: 188252-74-6.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-methyl-N-[[(4-methylbenzoyl)amino](phenyl)methyl]benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-[[(4-methylbenzoyl)amino](phenyl)methyl]benzamide(188252-74-6)
• EPA Substance Registry System: 4-methyl-N-[[(4-methylbenzoyl)amino](phenyl)methyl]benzamide(188252-74-6)

Safety Data

• Hazardous Substances Data: 188252-74-6(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 619-55-6 para-methylbenzamide 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

The synthesis and structure of pyridine-oxadiazole iridium complexes and catalytic applications: Non-coordinating-anion-tuned selective C–N bond formation

Several novel pyridine-oxadiazole iridium complexes were synthesized and characterized through X-ray crystallography. The designed iridium complexes revealed surprisingly high catalytic activity in C–N bondformation of amides and benzyl alcohols with the assistance of non-coordinating anions. In an attempt to achieve borrowing hydrogen reactions of amides with benzyl alcohols, N,N'-(phenylmethylene)dibenzamide products were unexpectedly isolated under non-coordinating anion conditions, whereas N-benzylbenzamide products were achieved in the absence of non-coordinating anions. The mechanism explorations excluded the possibility of “silver effect” (silver-assisted or bimetallic catalysis) and revealed that the reactivity of iridium catalyst was varied by non-coordinating anions. This work provided a convenient and useful methodology that allowed the iridium complex to be a chemoselective catalyst and demonstrated the first example of non-coordinating-anion-tuned selective C–N bond formation

Molybdate and silica sulfuric acids as heterogeneous alternatives for synthesis of gem-bisamides and bisurides from aldehydes and amides, carbamates, nitriles or urea

Molybdate sulfuric acid (MSA) and silica sulfuric acid (SSA) has been prepared and used as efficient solid catalysts for the synthesis of gem-bisamides and bisurides via the one-pot three-component reaction of two moles of amides, nitriles, carbamates or urea with aldehydes. The catalytic efficiency of SSA, MSA, or H2SO4 98% per H+ sites as turnover number (TON), turnover frequency (TOF), and atomic economy (AE) was calculated and compared for quantitative evaluation of catalysts. The AE, TON, and TOF factors show the superiority of the SSA versus MSA and H 2SO4. Short reaction times, simple work-up, chemoselectivity, low loading, and reusability of solid acid catalysts are extra advantages than current methods reported in the literature with corrosive acidic catalysts.

Efficient synthesis of symmetrical bisamides from aldehydes and amides catalyzed by silica-bonded S-sulfonic acid nanoparticles

Silica-bonded S-sulfonic acid nanoparticles (SBSSANPs) were easily synthesized from silica nanoparticles and showed to be an efficient catalyst in the synthesis the symmetrical N,N′-alkylidene bisamides. Reaction of aldehydes and amides in the presence of the catalyst afforded the corresponding bisamides in good to excellent yields. The extensive range of substrates suggests general applicability of the method. Reusability of the catalyst, simple workup procedure, and short reaction times are other advantages of this protocol. Copyright