- Microwave-assisted direct amidation of ethyl 1-phenyl-5-hydroxy-1H-pyrazole-4-carboxylate
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Microwave-assisted treatment of ethyl 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylate with excess primary aliphatic amines in 1-propanol at 140C and with excess pyrrolidine or piperidine in 2-methoxyethanol at 180C produced the corresponding carboxamides in
- Milo?evic, Mladena,?terbal, Ines,Fegu?, Urban,Ba?kov?, Jernej,Prek, Benjamin,Gro?elj, Uro?,Stanovnik, Branko,Svete, Jurij
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- Enaminones as building blocks in organic synthesis: Synthesis of new polyfunctional pyridines, condensed pyridines, and penta substituted benzene
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Several new thienopyridine and methylthioether derivatives have been synthesized. New synthesis of pyrido[2,3-b]-thieno[3,2-d]pyrimidine and penta substituted benzene were achieved.
- Abu-Shanab,Elkholy,Elnagdi
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- Synthetic method of diethyl dimethylaminomethylenemalonate
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The invention belongs to the technical field of chemical synthesis, and concretely relates to a synthetic method of diethyl dimethylaminomethylenemalonate. The synthetic method provided by the invention includes the following steps: (1) reacting a compound I with a compound II at 70-90 DEG C to obtain a compound III; and (2) reacting the compound III and a compound IV with organic solvents at 20-30 DEG C in the presence of a catalyst and organic bases to obtain a compound V. The synthetic method of the invention is high in product yield, low in production cost, simplified in post-treatment operation, energy saving, environmentally friendly, and easy in large-scale production. The concrete synthetic route is shown in the description.
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Paragraph 0024; 0025; 0026; 0027
(2019/05/08)
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- ORTHOAMIDES, XLVIII REACTIONS OF AN AZAVINYLOGUE AMINALESTER WITH CH2-ACIDIC COMPOUNDS
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Condensation reactions of azavinylogue orthoamides 5a and 6a with CH2-acidic compounds are described.Reaction products are formylated - or azavinylogue formylated compounds 8 and 9 resp.The condensation reactions of 5a can be enhanced by addition of trimethyl borate.Under these conditions the formylations reaction-leading to compounds of type 8 - is preferred.
- Kantlehner, Willi,Hauber, Michael
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p. 697 - 704
(2007/10/02)
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- VICINAL TRICARBONYL PRODUCTS FROM SINGLET OXYGEN REACTIONS. APPLICATION TO THE SYNTHESIS OF CARBACEPHAMS.
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Vicinal tricarbonyl systems are readily formed by reacting β-dicarbonyl precursors with DMF acetal to form enamines which are then cleaved by photooxidation.This procedure may be applied to the formation of carbacephams.
- Wasserman, Harry H.,Han, William T.
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p. 3743 - 3746
(2007/10/02)
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- REACTION OF GOLD'S REAGENT WITH ACTIVATED METHYLENE GROUPS DERIVED FROM ESTERS AND NITROARENES
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A series of esters and nitrotoluenes were reacted with Gold's reagent under basic conditions and were found to produce the corresponding dimethylamino methyleneated product in both cases.
- Gupton, John T.,Lizzi, Michael J.,Polk, Dale
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p. 939 - 946
(2007/10/02)
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