18856-68-3

Usage

Uses

Used in Pharmaceutical Industry:
DIETHYL DIMETHYLAMINOMETHYLENEMALONATE is used as a key intermediate for the synthesis of chemotherapeutic agents, particularly those derived from 6-aminobenzothiazoles. Its versatile chemical structure enables the development of novel and effective cancer treatments, targeting various types of malignancies and improving patient outcomes.

InChI:InChI=1/C10H17NO4/c1-5-14-9(12)8(7-11(3)4)10(13)15-6-2/h7H,5-6H2,1-4H3

Upstream product

• 124-40-3 dimethyl amine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 105-53-3 diethyl malonate 
• 21511-55-7 (methoxymethylidene)dimethylammonium methyl sulfate 
• 20353-93-9 Gold's reagent 
• 119522-06-4 Di-tert-butylphosphine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 609-09-6 Diethyl ketomalonate 
• 34667-64-6 3-ethoxycarbonyl-8-methyl-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 21203-19-0 1-cyano-3-ethoxycarbonyl-4-oxo-4H-quinolizine 
• 54401-76-2 diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate 
• 4105-92-4 triethyl benzene-1,3,5-tricarboxylate 
• 59591-74-1 Diaethyl-N-(indazolyl-3)aminoaethylenmalonat 
• 74414-00-9 5-ethoxycarbonyl-3-methyl-1-phenyl-6-oxo-1(6H)-pyrano<2,3-c>pyrazole 
• 54132-81-9 diethyl 2-(1-carboxymethylaminomethylene)propane-1,3-dicarboxylate 
• 332066-58-7 3-ethoxy-1H-pyrazole-4-carboxylic acid ethyl ester 
• 7251-53-8 ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 71083-00-6 ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 
• 1438234-19-5 (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-6-fluoro-1-methyl-1,4-dihydroquinoline-3-carboxylate 
• 1438234-23-1 (E)-ethyl 4-([1,1'-biphenyl]-4-ylimino)-1-ethyl-6-fluoro-1,4-dihydroquinoline-3-carboxylate 
• 77779-49-8 4-chloro-6-fluoroquinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Microwave-assisted direct amidation of ethyl 1-phenyl-5-hydroxy-1H-pyrazole-4-carboxylate

Microwave-assisted treatment of ethyl 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylate with excess primary aliphatic amines in 1-propanol at 140C and with excess pyrrolidine or piperidine in 2-methoxyethanol at 180C produced the corresponding carboxamides in

Enaminones as building blocks in organic synthesis: Synthesis of new polyfunctional pyridines, condensed pyridines, and penta substituted benzene

Several new thienopyridine and methylthioether derivatives have been synthesized. New synthesis of pyrido[2,3-b]-thieno[3,2-d]pyrimidine and penta substituted benzene were achieved.

Synthetic method of diethyl dimethylaminomethylenemalonate

The invention belongs to the technical field of chemical synthesis, and concretely relates to a synthetic method of diethyl dimethylaminomethylenemalonate. The synthetic method provided by the invention includes the following steps: (1) reacting a compound I with a compound II at 70-90 DEG C to obtain a compound III; and (2) reacting the compound III and a compound IV with organic solvents at 20-30 DEG C in the presence of a catalyst and organic bases to obtain a compound V. The synthetic method of the invention is high in product yield, low in production cost, simplified in post-treatment operation, energy saving, environmentally friendly, and easy in large-scale production. The concrete synthetic route is shown in the description.

ORTHOAMIDES, XLVIII REACTIONS OF AN AZAVINYLOGUE AMINALESTER WITH CH2-ACIDIC COMPOUNDS

Condensation reactions of azavinylogue orthoamides 5a and 6a with CH2-acidic compounds are described.Reaction products are formylated - or azavinylogue formylated compounds 8 and 9 resp.The condensation reactions of 5a can be enhanced by addition of trimethyl borate.Under these conditions the formylations reaction-leading to compounds of type 8 - is preferred.

VICINAL TRICARBONYL PRODUCTS FROM SINGLET OXYGEN REACTIONS. APPLICATION TO THE SYNTHESIS OF CARBACEPHAMS.

Vicinal tricarbonyl systems are readily formed by reacting β-dicarbonyl precursors with DMF acetal to form enamines which are then cleaved by photooxidation.This procedure may be applied to the formation of carbacephams.

REACTION OF GOLD'S REAGENT WITH ACTIVATED METHYLENE GROUPS DERIVED FROM ESTERS AND NITROARENES

A series of esters and nitrotoluenes were reacted with Gold's reagent under basic conditions and were found to produce the corresponding dimethylamino methyleneated product in both cases.