18856-68-3

Basic information

• Product Name: DIETHYL DIMETHYLAMINOMETHYLENEMALONATE
• Synonyms: Diethyl 2-[(dimethylamino)methylene]malonate;Propanedioic acid, [(dimethylamino)methylene]-, diethyl ester;DIETHYL DIMETHYLAMINOMETHYLENEMALONATE;DIETHYL 2-[(DIMETHYLAMINO)METHYLIDENE]MALONATE;ethyl 3-(dimethylamino)-2-(ethoxycarbonyl)propenoate, tech.;N,N-Dimethylaminomethylenemalonic acid diethyl ester;ETHYL 3-(DIMETHYLAMINO)-2-(ETHOXYCARBONYL)PROPENOATE;Diethyl 2-[(dimethylamino)methylidene]propane-1,3-dioate
• CAS NO: 18856-68-3
• Molecular Formula: C₁₀H₁₇NO₄
• Molecular Weight: 215.25
• Mol File: 18856-68-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 134-136°C 0,5mm
• Flash Point: 134-136°C/0.5mm
• Appearance: /
• Density: 1.069g/cm³
• Vapor Pressure: 0.0336mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: 2-8°C
• Solubility: Soluble in methanol.
• CAS DataBase Reference: DIETHYL DIMETHYLAMINOMETHYLENEMALONATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIETHYL DIMETHYLAMINOMETHYLENEMALONATE(18856-68-3)
• EPA Substance Registry System: DIETHYL DIMETHYLAMINOMETHYLENEMALONATE(18856-68-3)

Safety Data

• Hazardous Substances Data: 18856-68-3(Hazardous Substances Data)

Usage

Uses

Derivatives of this compound, diethyl ethoxymethylenemalonate is used in the synthesis of chemotherapeutic agents using 6-aminobenzothiazoles as starting material.

InChI:InChI=1/C10H17NO4/c1-5-14-9(12)8(7-11(3)4)10(13)15-6-2/h7H,5-6H2,1-4H3

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 105-53-3 diethyl malonate 
• 21511-55-7 (methoxymethylidene)dimethylammonium methyl sulfate 
• 20353-93-9 Gold's reagent 
• 119522-06-4 Di-tert-butylphosphine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 124-40-3 dimethyl amine 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 609-09-6 Diethyl ketomalonate 
• 21203-19-0 1-cyano-3-ethoxycarbonyl-4-oxo-4H-quinolizine 
• 54401-76-2 diethyl 4-oxo-4H-quinolizine-1,3-dicarboxylate 
• 59591-74-1 Diaethyl-N-(indazolyl-3)aminoaethylenmalonat 
• 74414-00-9 5-ethoxycarbonyl-3-methyl-1-phenyl-6-oxo-1(6H)-pyrano<2,3-c>pyrazole 
• 54132-81-9 diethyl 2-(1-carboxymethylaminomethylene)propane-1,3-dicarboxylate 
• 16878-14-1 3-ethoxycarbonyl-9-methyl-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 50876-74-9 3-ethoxycarbonyl-9-hydroxy-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 7251-53-8 ethyl 3-oxo-2,3-dihydro-1H-pyrazole-4-carboxylate 
• 332066-58-7 3-ethoxy-1H-pyrazole-4-carboxylic acid ethyl ester 
• 30588-33-1 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester 
• 4105-92-4 triethyl benzene-1,3,5-tricarboxylate 
• 34667-64-6 3-ethoxycarbonyl-8-methyl-4-oxo-4H-pyrido<1,2-a>pyrimidine 
• 25770-53-0 N-tosyl-N',N'-dimethylformamidine 

Relevant articles and documents

Microwave-assisted direct amidation of ethyl 1-phenyl-5-hydroxy-1H-pyrazole-4-carboxylate

Microwave-assisted treatment of ethyl 5-hydroxy-1-phenyl-1H-pyrazole-4-carboxylate with excess primary aliphatic amines in 1-propanol at 140C and with excess pyrrolidine or piperidine in 2-methoxyethanol at 180C produced the corresponding carboxamides in

Enaminones as building blocks in organic synthesis: Synthesis of new polyfunctional pyridines, condensed pyridines, and penta substituted benzene

Several new thienopyridine and methylthioether derivatives have been synthesized. New synthesis of pyrido[2,3-b]-thieno[3,2-d]pyrimidine and penta substituted benzene were achieved.

ORTHOAMIDES, XLVIII REACTIONS OF AN AZAVINYLOGUE AMINALESTER WITH CH2-ACIDIC COMPOUNDS

Condensation reactions of azavinylogue orthoamides 5a and 6a with CH2-acidic compounds are described.Reaction products are formylated - or azavinylogue formylated compounds 8 and 9 resp.The condensation reactions of 5a can be enhanced by addition of trimethyl borate.Under these conditions the formylations reaction-leading to compounds of type 8 - is preferred.