188745-01-9Relevant articles and documents
Transition-state inhibitors for nucleoside hydrolase and transferase reactions
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, (2008/06/13)
This invention is directed to transition-state analog compounds and to the use of said compounds as inhibitors of nucleoside hydrolase and transferase enzyme activity of parasites. This invention is further directed to the use of said compounds to treat infections and diseases caused by certain bacterial and plant toxins.
Synthesis of transition state inhibitors for N-riboside hydrolases and transferases
Furneaux, Richard H.,Limberg, Gerrit,Tyler, Peter C.,Schramm, Vern L.
, p. 2915 - 2930 (2007/10/03)
A number of 1,4-dideoxy-1,4-imino-1-(S)-(substituted phenyl)-D-ribitols bearing aromatic OH, NH2, NO2, CO2H and halogeno moieties, and a 3-pyridyl analogue have been synthesized. The key step is die condensation of aryllithium or aryl Grignard reagents with the imine 3; derived from the protected 1,4-dideoxy-1,4-imino-D-ribitol 4.