Design and synthesis of noncompetitive metabotropic glutamate receptor subtype 5 antagonists
A series of diaryl amides was designed and synthesized as novel nonethynyl mGluR5 antagonists. The systematic variation of the pharmacophoric groups led to the identification of a lead compound that demonstrated micromolar affinity for the mGluR5. Further optimization resulted in compounds with improved binding affinities and antagonist profiles, in vitro.
Kulkarni, Santosh S.,Nightingale, Barbara,Dersch, Christina M.,Rothman, Richard B.,Newman, Amy Hauck
p. 3371 - 3375
(2007/10/03)
Assembling Organic Receptors around Transition Metal Templates: Functionalized Catechols and Dioxomolybdenum(VI) for the Recognition of Dicarboxylic Acids
The synthesis of two receptors for dicarboxylic acids [12]2- and [13]2-, based on the self arrangement of two functionalized catechols 1 and 2 around a cis-[MoO2]2+ core, is described. Among the three pairs of e
Prévot-Halter, Isabelle,Smith, Thomas J.,Weiss, Jean
p. 2186 - 2192
(2007/10/03)
More Articles about upstream products of 188747-28-6