Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4- (alkylamino)-5-nitroquinoline bioreductive drugs
Studies have shown that 4-(alkylamino)-5-nitroquinolines possess high selectivity (20-60-fold) for hypoxic tumor cells in vitro, but are not active as hypoxia-selective cytotoxins (HSCs) in vivo. The compounds show inadequate rates of extravascular diffus
Siim, Bronwyn G.,Atwell, Graham J.,Anderson, Robert F.,Wardman, Peter,Pullen, Susan M.,Wilson, William R.,Denny, William A.
p. 1381 - 1390
(2007/10/03)
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