SIMPLE SYNTHESIS AND SEPARATION OF THE DIASTEREOMERS OF α-THIO ANALOGS OF RIBO- AND DEOXYRIBO- DI- AND TRIPHOSPHATES
Nucleoside 5'-O-(1-thiodi-) and triphosphates can be obtained in yields of up to 45percent directly from the nucleosides.Their diastereomers can be separated by preparative reversed phase chromatography.
Synthesis of nucleoside α-thiotriphosphates via an oxathiaphospholane approach
(Chemical Equation Presented) Nucleoside 5′-O-(α- thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5′-O-(2-thio-1,3,2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of α-seleno congeners and corresponding α-modified diphosphates.
Misiura, Konrad,Szymanowicz, Daria,Stec, Wojciech J.
p. 2217 - 2220
(2007/10/03)
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