SIMPLE SYNTHESIS AND SEPARATION OF THE DIASTEREOMERS OF α-THIO ANALOGS OF RIBO- AND DEOXYRIBO- DI- AND TRIPHOSPHATES

Article abstract of DOI:10.1016/S0040-4039(00)84859-5

Nucleoside 5'-O-(1-thiodi-) and triphosphates can be obtained in yields of up to 45percent directly from the nucleosides.Their diastereomers can be separated by preparative reversed phase chromatography.