18895-10-8

Basic information

• Product Name: 4-BROMO-3-CYANOTHIOPHENE
• Synonyms: 4-BROMO-3-CYANOTHIOPHENE;4-BROMOTHIOPHENE-3-CARBONITRILE;3-Bromo-4-cyanothiophene;3-Bromothiophene-4-carbonitrile;4-Bromthiophene-3-carbonitrile;4-Bromothiophene-3-carbonitrile 97%
• CAS NO: 18895-10-8
• Molecular Formula: C₅H₂BrNS
• Molecular Weight: 188.04508
• Product Categories: Cyano;Organohalides;Thiophene
• Mol File: 18895-10-8.mol

Chemical Properties

• Melting Point: 58-62°C
• Boiling Point: 289.1 °C at 760 mmHg
• Flash Point: 128.7 °C
• Appearance: /
• Density: 1.82 g/cm³
• Vapor Pressure: 0.00224mmHg at 25°C
• Refractive Index: 1.641
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: 4-BROMO-3-CYANOTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-3-CYANOTHIOPHENE(18895-10-8)
• EPA Substance Registry System: 4-BROMO-3-CYANOTHIOPHENE(18895-10-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 18895-10-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-BROMO-3-CYANOTHIOPHENE is used as a synthetic intermediate for the creation of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-BROMO-3-CYANOTHIOPHENE serves as a key component in the synthesis of compounds used in pest control and crop protection, leveraging its reactivity to form effective agrochemicals.
Used in Material Science:
4-BROMO-3-CYANOTHIOPHENE is utilized as a precursor in the development of organic semiconductors, which are crucial for advancing electronic and optoelectronic device technologies. Its incorporation into these materials contributes to their performance and functionality.
Used in the Production of Liquid Crystals:
4-BROMO-3-CYANOTHIOPHENE is also used as a building block in the synthesis of liquid crystals, which are vital for display technologies and other applications requiring responsive molecular structures.
Used in Optoelectronic Device Development:
4-BROMO-3-CYANOTHIOPHENE contributes to the advancement of optoelectronic devices, such as solar cells and light-emitting diodes (LEDs), by providing a chemical foundation for the design of novel materials with improved light interaction properties.

InChI:InChI=1/C5H2BrNS/c6-5-3-8-2-4(5)1-7/h2-3H

Upstream product

• 18791-95-2 4-bromothiophene-3-carbaldehyde oxime 
• 3141-26-2 3,4-dibromothiophene 
• 557-21-1 dicyanozinc 
• 544-92-3 copper(I) cyanide 
• 18791-78-1 4-bromothiophene-3-carboxaldehyde 
• 100245-61-2 4-bromothiophene-3-carboxamide 
• 19158-51-1 P-toluenesulfonyl cyanide 
• 16694-17-0 4-bromo-3-thiophenecarboxylic acid 

Downstream Products

• 100245-61-2 4-bromothiophene-3-carboxamide 
• 1150566-11-2 t-butyl-4-(4-cyanothiophen-3-yl)phenylcarbamate 
• 1641-09-4 3-thiophenecarbonitrile 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Improved synthesis of 3-substituted-4-amino-[3,2-c]-thienopyridines

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HCV INHIBITORS

The present invention provides HCV polymerase inhibiting compounds having the formula (I) where R1is cyclobutyl-N(Ra)-, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-

Novel thiophenes and analogues with anthelmintic activity against Haemonchus contortus

A new series of analogues of 4-(4-fluorophenyl)-2-methylthio-thiophene-3- carbonitrile (1) were synthesized and evaluated for their in vitro and in vivo anthelmintic activity against Haemonchus contortus.

Palladium-Catalyzed Cyanation Reactions of Thiophene Halides

The described method provides an efficient cyanation reaction of thiophene halides using tris(dibenzylidene-acetone)dipalladium(0), 1,1′-bis- (diphenylphosphino)ferrocene) and zinc powder as the catalyst system and Zn(CN)2 as the cyanide source

Synthesis of Thieno--, -- and --thiophenes and Thieno--, -- and --thienopyrimidin-7(6H)-ones Starting from Thiophene

3-Bromo-, 3,5-dibromo- and 3,4,5-tribromo-2-thienyllithium have been prepared by bromine ->lithium exchange and converted into a number of thiophene derivatives, including the corresponding 2-carbaldehydes.The aldehydes have been converted into the corresponding thiophene-2-carbonitriles.Metallation of 2,5-dibromo- or 2,4,5-tribromo-thiophene with LDA occured at a vacant 3-position but the resulting 3-lithiated thiophenes rearranged (mechanism discussed) to 3,5-dibromo- and 3,4,5-tribromo-2-thienyllithium, which were quenched with various electrophiles.Attempts to dilithiate 2,5-dibromothiophene with LDA were unsuccessful. 3,4-Dibromo-2,5-dilithiothiophene was prepared from 2,3,4,5-tetrabromothiophene but it failed to yield the 2,5-dicarbaldehyde with N,N-dimethylformamide.The title thienothiophenes were prepared by reaction of a 3-bromothiophene-2-carbaldehyde, a 2-bromothiophene-3-carbaldehyde (prepared by bromination of a thiophene-3-carbaldehyde) or a 4-bromothiophene-3-carbaldehyde, or a corresponding nitrile, with ethyl 2-sulfanylacetate or 2-sulfanylacetamide.Thienothiophenes carrying an o-aminocarboxamide substitution pattern gave the title thienothienopyrimidinones with triethyl orthoformate.