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189345-04-8

(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate is a complex cephalosporin-based compound with a unique combination of chemical moieties, including a thiazole ring, a 1,2,4-thiadiazol ring, an ethoxyiminoacetamido side chain, and a pyridinium group. This molecule is likely to exhibit potent antibiotic properties and additional pharmacological activities due to its diverse structural components.

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  • (6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate

    Cas No: 189345-04-8

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  • weifang yangxu group co.,ltd
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  • Manufacturer Supply Top quality 6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3 -cephem-4-carboxylate

    Cas No: 189345-04-8

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  • Shaanxi Mingqi Chemical Co., Ltd
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  • 189345-04-8 Structure

  • Basic information

    1. Product Name: (6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate
    2. Synonyms: T-91825; PPI-0903M
    3. CAS NO:189345-04-8
    4. Molecular Formula: C22H20N8O5S4
    5. Molecular Weight: 604.7113
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 189345-04-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: (6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate(189345-04-8)
    11. EPA Substance Registry System: (6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate(189345-04-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 189345-04-8(Hazardous Substances Data)

189345-04-8 Usage

Uses

Used in Pharmaceutical Industry:
(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate is used as an antibiotic agent for the treatment of bacterial infections. Its cephalosporin core and the presence of a 1,2,4-thiadiazol ring may contribute to its potency and selectivity against a range of bacterial pathogens.
Used in Research and Development:
In the field of medicinal chemistry and pharmaceutical research, this compound serves as a valuable research tool for understanding the structure-activity relationships of cephalosporin-based antibiotics and exploring the potential synergistic effects of its various chemical moieties. This knowledge can be applied to the design and development of new, more effective, and targeted antibiotics.
Used in Drug Resistance Studies:
(6R,7R)-7-[(Z)-2-(5-Amino-1,2,4-thiadiazol-3-yl)-2-(ethoxyimino)acetamido]-3-[4-(1-methylpyridinium-4-yl)thiazol-2-ylsulfanyl]-3-cephem-4-carboxylate can be employed in studies aimed at understanding and overcoming antibiotic resistance in bacteria. Its unique structural features may provide insights into new strategies for combating resistant strains and developing novel therapeutic approaches.
Used in Drug Delivery Systems:
Similar to gallotannin, this complex cephalosporin compound may also benefit from novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. Researchers can explore various organic and metallic nanoparticles as carriers for improved administration and targeting of bacterial infections.

Check Digit Verification of cas no

The CAS Registry Mumber 189345-04-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,3,4 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 189345-04:
(8*1)+(7*8)+(6*9)+(5*3)+(4*4)+(3*5)+(2*0)+(1*4)=168
168 % 10 = 8
So 189345-04-8 is a valid CAS Registry Number.

189345-04-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ceftaroline

1.2 Other means of identification

Product number -
Other names UNII-H36Z0FHR8K

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189345-04-8 SDS

189345-04-8Downstream Products

189345-04-8Relevant articles and documents

TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties

Ishikawa, Tomoyasu,Matsunaga, Nobuyuki,Tawada, Hiroyuki,Kuroda, Noritaka,Nakayama, Yutaka,Ishibashi, Yukio,Tomimoto, Mitsumi,Ikeda, Yukihiro,Tagawa, Yoshihiko,Iizawa, Yuji,Okonogi, Kenji,Hashiguchi, Shohei,Miyake, Akio

, p. 2427 - 2437 (2007/10/03)

Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2′ (IC50; 0.90 μg/mL) and shows potent in v

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