189450-22-4

Basic information

• Product Name: D-Proline, 4-amino-5-oxo-, methyl ester, (4S)-rel- (9CI)
• Synonyms: D-Proline, 4-amino-5-oxo-, methyl ester, (4S)-rel- (9CI)
• CAS NO: 189450-22-4
• Molecular Formula: C6H10N2O3
• Molecular Weight: 158.1552
• Product Categories: CARBOXYLICESTER;GLYCINESCAFFOLD
• Mol File: 189450-22-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: D-Proline, 4-amino-5-oxo-, methyl ester, (4S)-rel- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: D-Proline, 4-amino-5-oxo-, methyl ester, (4S)-rel- (9CI)(189450-22-4)
• EPA Substance Registry System: D-Proline, 4-amino-5-oxo-, methyl ester, (4S)-rel- (9CI)(189450-22-4)

Safety Data

• Hazardous Substances Data: 189450-22-4(Hazardous Substances Data)

Upstream product

• 19255-80-2 5-methoxycarbonyl-pyrazoline-3-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 159206-44-7 meso-2,4-diaminoglutaric acid dihydrochloride 
• 180715-03-1 (2S,4R)-2-Benzoylamino-4-tert-butoxycarbonylamino-pentanedioic acid dimethyl ester 

Relevant articles and documents

Catalytic hydrogenation of methyl esters of some 1H-pyrazoline-3-carboxylic acids

Hydrogenation over Raney nickel of the methyl ester of 1H-pyrazoline-3- carboxylic acid and also of its 4-phenyl and 5-methoxycarbonyl-substituted analogs, leads respectively to 3-aminopyrrolidin-2-one, its 4-phenyl- and 5-methoxycarbonyl derivatives, pre

Asymmetric synthesis of meso- and (2R,4R)-2,4-diaminoglutaric acids

In order to synthesize meso- and (2R,4R)-2,4-diaminoglutaric acids, a synthetic route has been developed starting from Garner's aldehyde and where the key steps are the asymmetric hydrogenations of (E)- and (Z)-(R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-[2'-(benzamido)-2' -(methoxycarbonyl)ethenyl]-1,3-oxazolidine, under heterogeneous conditions, followed by oxidation and further hydrolysis. A model is proposed to explain the stereochemical outcome of the asymmetric hydrogenation.