189500-02-5 Usage
Chemical family
Cycloocta[b]quinoline This compound belongs to a family of chemical compounds that have a cyclooctane ring fused to a quinoline ring.
Heterocyclic compound
Contains atoms of at least two different elements in its rings This property indicates that the compound has a ring structure made up of different types of atoms, which can contribute to its unique chemical properties.
Amino group
Contains a nitrogen atom bonded to a hydrogen atom and an alkyl group The presence of an amino group can influence the compound's reactivity, solubility, and potential biological activity.
Methyl group
Contains a single carbon atom bonded to three hydrogen atoms The methyl group is a common functional group in organic chemistry, and its presence can affect the compound's steric and electronic properties.
7(S) and 11(S) configuration
The stereochemistry at positions 7 and 11 is in the (S) configuration This refers to the three-dimensional arrangement of the atoms in the molecule, which can have significant effects on the compound's properties and potential applications.
Potential biological and medicinal applications
Cycloocta[b]quinoline compounds have been studied for their potential in various fields This suggests that the compound may have interesting properties and uses in chemistry and pharmacology, although further research is needed to fully understand its potential.
Additional research and testing
Necessary to fully understand the properties and potential uses of this specific compound This highlights the need for further investigation to determine the compound's characteristics and how it might be applied in practical settings.
Chemical structure
A complex arrangement of atoms, including a cyclooctane ring fused to a quinoline ring, an amino group, a methyl group, and specific stereochemistry at positions 7 and 11 This provides a detailed description of the compound's molecular structure, which is essential for understanding its properties and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 189500-02-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,5,0 and 0 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 189500-02:
(8*1)+(7*8)+(6*9)+(5*5)+(4*0)+(3*0)+(2*0)+(1*2)=145
145 % 10 = 5
So 189500-02-5 is a valid CAS Registry Number.
189500-02-5Relevant articles and documents
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors
Camps,Gómez,Mu?oz-Torrero,Badia,Vivas,Barril,Orozco,Luque
, p. 4733 - 4736 (2001)
Two 12-amino-6,7,8,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [9-Me(Et)] (syn-huprines) have been obtained by condensation of known 7-alkylbicyclo[3.3.1]non-6-en-3-ones with 2-(trifluoromethyl)aniline, followed by basic cyclization of the resulting imine, and chromatographic separation of the regioisomeric mixture of products, thus obtained. The new (±)-syn-huprines were shown to be slightly less active bovine or human acetylcholinesterase inhibitors than the corresponding anti-derivatives. Molecular modeling simulations allow us to explain the differences in inhibitory activity of these compounds on the basis of an inverse solvation effect.
Synthesis and evaluation of tacrine-huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease
Badia, Albert,Banos, Josep E.,Camps, Pelayo,Contreras, Joan,Goerbig, Diana M.,Munoz-Torrero, Diego,Simon, Montserrat,Vivas, Nuria M.
, p. 427 - 440 (1998)
Seventeen polycyclic compounds related to tactine and huperzine A have been prepared as racemic mixtures and tested as acetylcholinesterase (ACHE) inhibitors. The conjunctive pharmacomodulation of huperzine A (carbobicyclic substructure) and tactine (4-aminoquinoline substructure) led to compound 7jy, 2.5 times less active than tacrine as AChE inhibitor, but much more active than its (Z)-stereoisomer (7iy). Derivatives 7dy and 7ey, lacking the ethylidene substituent, showed to be more active than tactine. Many other structural modifications of 7jy led to less active compounds. Compounds 7dy and 7ey also showed to be much more active than tactine in reversing the partial neuromuscular blockade induced by d-tubocurarine.
