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CAS

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18956-18-8

DIHYDROOROXYLIN, also known as (S)-5,7-Dihydroxy-6-methoxy-2-phenylchroman-4-one, is a natural flavonoid derivative that has been isolated from Pisonia aculeata. It is characterized by its unique structure, featuring hydroxy groups at positions 5 and 7, and a methoxy group at position 6. DIHYDROOROXYLIN exhibits significant antitubercular activity, making it a promising candidate for pharmaceutical applications.

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  • 18956-18-8 Structure

  • Basic information

    1. Product Name: DIHYDROOROXYLIN
    2. Synonyms: DIHYDROOROXYLIN;5,7-Dihydroxy-6-methoxyflavanone;Dihydrooroxylin A
    3. CAS NO:18956-18-8
    4. Molecular Formula: C16H14O5
    5. Molecular Weight: 286.282
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 18956-18-8.mol

  • Chemical Properties

    1. Melting Point: 166℃
    2. Boiling Point: 543.2°Cat760mmHg
    3. Flash Point: 207.3°C
    4. Appearance: /
    5. Density: 1.370±0.06 g/cm3 (20 ºC 760 Torr)
    6. Vapor Pressure: 2.06E-12mmHg at 25°C
    7. Refractive Index: 1.637
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: 7.51±0.40(Predicted)
    11. CAS DataBase Reference: DIHYDROOROXYLIN(CAS DataBase Reference)
    12. NIST Chemistry Reference: DIHYDROOROXYLIN(18956-18-8)
    13. EPA Substance Registry System: DIHYDROOROXYLIN(18956-18-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 18956-18-8(Hazardous Substances Data)

18956-18-8 Usage

Uses

Used in Pharmaceutical Industry:
DIHYDROOROXYLIN is used as an antitubercular agent for its ability to inhibit the growth and progression of tuberculosis. Its effectiveness against this disease is attributed to its unique chemical structure, which allows it to target and disrupt the biological processes of the tuberculosis-causing bacteria.
Used in Antiviral Applications:
In addition to its antitubercular properties, DIHYDROOROXYLIN is also used as an antiviral agent. It has been reported to act as an inhibitor of AMV (Avian Myeloblastosis Virus) and HIV reverse transcriptase (RT), which are essential enzymes for the replication of these viruses. By inhibiting these enzymes, DIHYDROOROXYLIN can potentially slow down or prevent the spread of viral infections, making it a valuable tool in the development of antiviral therapies.
Used in Drug Development:
Given its antitubercular and antiviral activities, DIHYDROOROXYLIN can be further explored and developed as a potential therapeutic agent for various diseases. Researchers can investigate its potential synergistic effects when combined with other drugs, as well as its ability to enhance the efficacy of existing treatments. This may lead to the development of novel drug delivery systems or combination therapies that can improve patient outcomes and address drug resistance issues.

Check Digit Verification of cas no

The CAS Registry Mumber 18956-18-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,9,5 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 18956-18:
(7*1)+(6*8)+(5*9)+(4*5)+(3*6)+(2*1)+(1*8)=148
148 % 10 = 8
So 18956-18-8 is a valid CAS Registry Number.
InChI:InChI=1/C16H14O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-6,8,12,18-19H,7H2,1H3/t12-/m0/s1

18956-18-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (2S)-5,7-dihydroxy-6-methoxy-2-phenyl-2,3-dihydrochromen-4-one

1.2 Other means of identification

Product number -
Other names 5,7-dihydroxy-6-methoxy-2-phenyl-chroman-4-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18956-18-8 SDS

18956-18-8Relevant articles and documents

A new domino oxidation—rearrangement of 2,3-dihydrowogonin to negletein

Spoerlein-Guettler, Cornelia,Milius, Wolfgang,Obenauf, Johannes,Schobert, Rainer

, p. 1560 - 1562 (2018/03/29)

We report an expeditious, iodine-catalysed oxidation of 2,3-dihydrowogonin to negletein which comprises a Wessely–Moser rearrangement (WMR), associated not with an O-demethylation, as usual, but with an oxygen to oxygen methyl shift. In contrast, DDQ in 1

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