189886-40-6Relevant articles and documents
Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds
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, (2008/06/13)
The present invention relates to a novel process for the preparation of a diastereomeric mixture of piperidinylaminomethyl trifluoromethyl cyclic ether compounds of formulae Ia and Ib: and pharmaceutically acceptable salts thereof, wherein R1is
Synthesis of tetrahydroquinolines, hexahydrobenzoindolizines and an aryl phosphonate linker for the generation of catalytic antibodies
Gonzalez-Bello, Concepcion,Abell, Chris,Leeper, Finian J.
, p. 1017 - 1024 (2007/10/03)
Syntheses of 6-methoxy-1-methyl-1,2,3,4-tetrahydroquinoline-3-methanol 10 and 1,2,3,5,6,10b-hexahydrobenzo[g]indolizine-6-methanol 34 are described. The aryl phosphonic acid 14, which can be used as a linker to a protein, is synthesised and coupled to the above alcohols. These haptens, when linked to a protein, are intended to generate antibodies able to catalyse cationic cyclisation reactions.