- Imidazole heterocyclic diphosphonic acid compound as well as preparation method and application thereof
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The invention belongs to the field of pharmaceutical chemistry, and in particular relates to an imidazole heterocyclic diphosphonic acid compound as well as a preparation method and application thereof. The imidazole heterocyclic diphosphonic acid compound has a larger non-toxic concentration range for an osteoclast precursor, and can significantly inhibit the formation of osteoclasts at the same time; the imidazole heterocyclic diphosphonic acid compound can damage actin ring to the utmost extent, thus having an obvious inhibiting effect on the osteoclasts and further being used as an osteoclast inhibitor; the imidazole heterocyclic diphosphonic acid compound solves the problems that diphosphonate in the prior art is low in inhibiting effect on the osteoclasts, high in toxicity and large in side effects.
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Paragraph 0086; 0087
(2017/07/20)
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- Disphosphonic acid derivatives, processes for their production and pharmaceutical preparations containing these compounds
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The present invention concerns novel disphosphonates having the general formula I STR1 in which Het represents a heterocyclic five-membered ring with 2-4 heteroatoms which is substituted, if desired, and which can also be partially hydrogenated, R1 -R7 each denote, independently of each other, hydrogen or C1 -C5 alkyl, X=denotes hydrogen, OH or the group --NR8 R9, in which R8 and R9 should each be, independently of each other, hydrogen or C1 -C5 alkyl, m and n denote, independently of each other, 0, 1 or 2, as well as their pharmacologically safe salts and optically active forms.
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