Solvent-free microwave synthesis of 3-(4-benzo[b]-thiophene-2-carbonyl)-1-piperazinyl-1-benzo[b]thiophen-2-YL-1-propanones. New hetero bis-ligands with potential 5-HT1A serotonergic activity
A novel series of 2-benzothiophenealkylpiperazine derivatives 11 (a-d) with potential affinity at 5-HT1A serotonin receptors have been synthesized via solvent-free, microwave-promoted Michael addition of benzo[b]thiophene piperazine derivatives 6(a-c) to substituted benzo[b]thiophen-2-yl propenones 10(b,c).
Pessoa-Mahana, Hernan,Kosche C., Johann,Ron H., Nadia,Recabarren-Gajardo, Gonzalo,Saitz B., Claudio,Araya-Maturana, Ramiro,Pessoa-Mahana, C. David
experimental part
p. 1913 - 1929
(2009/04/06)
Synthesis of 2-benzothienyl carbonyl 4-arylpiperazines as novel delavirdine analogs
A novel series of 2-benzothienyl carbonyl arylpiperazines (6a-f) was synthesized as potential HIV nonnucleoside reverse transcriptase inhibitors (NNRTIs). Preparation of the derivatives was performed by reacting benzo[b]thiophene carbonyl chloride (5) wit
Pessoa-Mahana, Hernan,Acevedo, R. Rodrigo,Saitz, B. Claudio,Araya-Maturana, Ramiro,Pessoa-Mahana
p. 1227 - 1235
(2008/02/01)
Synthesis of benzo[b]thiophene carboxamides connected to 4-arylpiperazines through a benzylic spacer: Potential ligands with 5-HT1A binding affinity
New benzothiophene arylpiperazine derivatives 8 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by treating N-[2-(chloromethyl)phenyl]-4,7- dimethoxybenzo[b]thiophene-2-
Pessoa-Mahana, Hernan,Acevedo,Araya-Maturana, Ramiro,Saitz, Claudio,Pessoa-Mahana, C. David
p. 3559 - 3567
(2008/03/13)
A concise synthesis of further thiophene analogues of kuanoniamine a
An efficient synthesis of three novel 9H-pyrido[6,5,4-kl]thieno[3,2-i]acridin-9-ones is described. The synthesis is achieved utilizing methyl-4,7-dimethoxybenzo[b]thiophene-2-carboxylate.
Hepburn, Seon A.,Jackson, Yvette A.
p. 975 - 981
(2007/10/03)
Studies on quinones: Part 30. Synthesis of benzo[b]thiophene-4,7- quinones
The synthesis of a variety of benzo[b]thiophene-4,7-quinones (4a-f) by oxidative demethylation of the corresponding 4,7-dimethoxybenzo[b]thiophenes (3a-f) with cerium (IV) ammonium nitrate is reported. Heterocycles (3a,b) were prepared by cyclization of t
Valderrama, Jaime A.,Valderrama, Claudio
p. 2143 - 2157
(2007/10/03)
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