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190511-51-4

N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 190511-51-4 Structure

  • Basic information

    1. Product Name: N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide
    2. Synonyms: N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide
    3. CAS NO:190511-51-4
    4. Molecular Formula: C14H12N4O
    5. Molecular Weight: 252.27128
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 190511-51-4.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide(190511-51-4)
    11. EPA Substance Registry System: N-methyl-N-phenyl-1H-1,2,3-benzotriazole-1-carboxamide(190511-51-4)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 190511-51-4(Hazardous Substances Data)

190511-51-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 190511-51-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,9,0,5,1 and 1 respectively; the second part has 2 digits, 5 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 190511-51:
(8*1)+(7*9)+(6*0)+(5*5)+(4*1)+(3*1)+(2*5)+(1*1)=114
114 % 10 = 4
So 190511-51-4 is a valid CAS Registry Number.

190511-51-4Relevant articles and documents

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

Kiss, László E.,Beliaev, Alexandre,Ferreira, Humberto S.,Rosa, Carla P.,Bonifácio, Maria Jo?o,Loureiro, Ana I.,Pires, Nuno M.,Palma, P. Nuno,Soares-da-Silva, Patrício

supporting information, p. 2177 - 2188 (2018/09/25)

Fatty acid amide hydrolase (FAAH) can be targeted for the treatment of pain associated with various medical conditions. Herein we report the design and synthesis of a novel series of heterocyclic-N-carboxamide FAAH inhibitors that have a good alignment of potency, metabolic stability and selectivity for FAAH over monoacylglycerol lipase (MAGL) and carboxylesterases (CEs). Lead optimization efforts carried out with benzotriazolyl- and imidazolyl-N-carboxamide series led to the discovery of clinical candidate 8 l (3-(1-(cyclohexyl(methyl)carbamoyl)-1H-imidazol-4-yl)pyridine 1-oxide; BIA 10-2474) as a potent and long-acting inhibitor of FAAH. However, during a Phase I clinical trial with compound 8 l, unexpected and unpredictable serious neurological adverse events occurred, affecting five healthy volunteers, including the death of one subject.

PHARMACEUTICAL COMPOUNDS

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Page/Page column 183, (2012/03/27)

The invention relates to compounds and compositions for inhibiting the enzyme fatty acid amide hydrolase (FAAH), the use of the compounds in therapy and, in particular, for treating or preventing conditions whose development or symptoms are linked to subs

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