40669-49-6

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 100-61-8 N-methylaniline 
• 91429-74-2 N,N-dimethyl-2-(methyl(phenyl)amino)acetamide 
• 104-87-0 4-methyl-benzaldehyde 
• 121-69-7 N,N-dimethyl-aniline 
• 614-30-2 N-methyl-N-phenyl-benzenemethanamine 
• 1088708-77-3 3-(N-methyl-N-phenylamino)-N,N-dimethylpropanamide 
• 21911-74-0 (methyl-phenyl-amino)-acetic acid ethyl ester 
• 201230-82-2 carbon monoxide 
• 624-31-7 4-tolyl iodide 
• 104-09-6 4-methylphenylacetaldehyde 
• 17873-01-7 (4-methylphenyl)trimethoxysilane 
• 37952-94-6 N-(4-methylbenzoyl) saccharin 
• 99-75-2 4-methyl-benzoic acid methyl ester 

Downstream Products

• 99-75-2 4-methyl-benzoic acid methyl ester 
• 100-61-8 N-methylaniline 
• 99293-87-5 N-(4-hydroxymethyl-benzoyl)-N-methylaniline 
• 1517-46-0 4-chloro-N-methyl-N-phenyl-benzamide 
• 33672-81-0 4-methoxy-N-methyl-N-phenylbenzamide. 
• 22911-22-4 1-methyl-4-(trimethoxymethyl)benzene 
• 6833-18-7 4-methyl-N-phenylbenzamide 
• 6876-66-0 4,4'-dimethylbenzanilide 
• 16547-09-4 N-methyl-N-(4-methylbenzyl)aniline 
• 110809-22-8 N-methyl-N-(p-toluoyl)-o-aminophenol 
• 886840-94-4 (Dimethoxy-p-tolyl-methyl)-methyl-phenyl-amine 

Relevant academic research and scientific papers

Nickel-Catalyzed Oxidative Transamidation of Tertiary Aromatic Amines with N -Acylsaccharins

The use of tertiary amines as surrogates for secondary amines has prominent advantages in terms of stabilization and ease of handling. A Ni-catalyzed transamidation of N -acylsaccharins with tertiary aromatic amines is reported. By using tert -butyl hydroperoxide as the terminal oxidant, this reaction permits selective cleavage of the C(sp 3)-N bonds of unsymmetrical tertiary aromatic amines depending on the sizes of the alkyl substituents.

Palladium-Catalyzed Desulfurative Hiyama Coupling of Thioureas to Achieve Amides via Selective C-N Bond Cleavage

Palladium-catalyzed Hiyama coupling of active thioureas via selective C-N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF 2as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.

Facile amidation of esters with aromatic amines promoted by lanthanide tris (amide) complexes

The development of catalysts capable of catalyzing amidation of esters with amines to construct amides under mild conditions is of great importance. Compared to aliphatic amines, the direct catalytic amidation of esters with less nucleophilic aromatic amines is rather difficult. Employing simple lanthanide tris (amide) complexes Ln[N (SiMe3)2]3(μ-Cl)Li (THF)3 as the catalysts, it was found a broad range of aromatic amines and esters were efficiently converted into various amides in good yields under mild conditions. A plausible mechanism for this transformation was experimentally supported as starting from an amide exchange reaction between the lanthanide tris (amide) complex and the substrate amine.

Enantioselective Desymmetrization of cis-3,5- O-Arylidenecyclohexanones Catalyzed by Cinchona-Derived Quaternary Ammonium Salts

An enantioselective protocol for the desymmetrization of cis-3,5-O-arylidenecyclohexanones has been developed that proceeded under the catalysis of readily available and inexpensive Cinchona-derived quaternary ammonium salts. The synthetic relevance of the methodology was exemplified by the synthesis of a key intermediate that could be used in the preparation of the active pharmaceutical ingredient, paricalcitol (Zemplar).

MALONONITRILE OXIME ETHER COMPOUND AND USE THEREOF

Disclosed is a malononitrile oxime ether compound having a novel structure as shown in the general formula I. Respective substituents in the general formula I as defined in the specification. The compound of the general formula I exhibits an excellent microbicidal activity, and can effectively prevent and treat plant diseases caused by bacteria and fungi. Also provided is a use of the compound of the general formula I as a microbicide in the agricultural and other fields.

Palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines

A novel and efficient palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of a variety of valuable imides and tertiary benzanilides under an atmospheric pressure of CO. Copyright

The nBu4NI catalysed oxidative benzoic acid amide formation from aryl acetaldehydes and amines in aqueous solution

A metal-free amide synthesis from aryl acetaldehydes and secondary aromatic amines via a carbon degradation process using nBu4NI/TBHP system in aqueous solution is described. This protocol has not been reported previously. Both substrates are cheap and readily available.

Iron-catalyzed oxidative amidation of tertiary amines with aldehydes

Unconventional couple: A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.

NBu4NI-catalyzed oxidative amidation of aldehydes with tertiary amines

An efficient oxidative coupling protocol for amide formation has been developed. Various tertiary amines and aromatic aldehydes were oxidized to their corresponding tertiary amides in moderate to good yields in the presence of a simple nBu4NI-catalyst.