19054-57-0

Basic information

• Product Name: SODIUM 2-HYDROXYBUTYRATE
• Synonyms: (+/-)-2-HYDROXYBUTANOIC ACID SODIUM SALT;2-HYDROXYBUTYRIC ACID SODIUM SALT;DL-2-HYDROXY-N-BUTYRIC ACID SODIUM SALT;DL-2-HYDROXYBUTYRIC ACID SODIUM SALT;SODIUM DL-2-HYDROXY-N-BUTYRATE;SODIUM 2-HYDROXYBUTYRATE;DL-2-Hydroxy-n-butyric acid sodium sal;sodium DL-2-hydroxybutyrate
• CAS NO: 19054-57-0
• Molecular Formula: C₄H₇O₃*Na
• Molecular Weight: 126.09
• EINECS: 225-812-4
• Mol File: 19054-57-0.mol

Chemical Properties

• Melting Point: 133-135 °C(lit.)
• Boiling Point: 238.3°Cat760mmHg
• Flash Point: 112.2°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.00759mmHg at 25°C
• CAS DataBase Reference: SODIUM 2-HYDROXYBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: SODIUM 2-HYDROXYBUTYRATE(19054-57-0)
• EPA Substance Registry System: SODIUM 2-HYDROXYBUTYRATE(19054-57-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 22-24/25
• WGK Germany: 3
• F: 3
• Hazardous Substances Data: 19054-57-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Production:
Sodium 2-hydroxybutyrate is used as an essential component in the creation of various pharmaceuticals due to its potential therapeutic effects on different medical conditions.
Used in Scientific Research:
As a research tool, sodium 2-hydroxybutyrate aids in studying the underlying mechanisms of neurological disorders, heart disease, and metabolic disorders, contributing to the advancement of medical knowledge in these areas.
Used in Neurological Disorder Treatment:
Sodium 2-hydroxybutyrate is used as a potential treatment for neurological disorders, leveraging its capacity to influence brain function and improve cognitive abilities.
Used in Heart Disease Treatment:
It is employed as a potential therapeutic agent for heart disease, given its metabolic properties and the possibility of enhancing heart health.
Used in Metabolic Disorder Treatment:
Sodium 2-hydroxybutyrate is used as a potential treatment for metabolic disorders, capitalizing on its role in fat breakdown and energy production.
Used in Cognitive Function Enhancement:
It is utilized for improving cognitive function, as research suggests that it may have brain energy supply benefits and positively affect cognitive performance.
Used in Antioxidant and Anti-Inflammatory Treatments:
Sodium 2-hydroxybutyrate is used in the development of treatments that harness its antioxidant and anti-inflammatory properties, potentially leading to new medical interventions for various conditions.

InChI:InChI=1/C4H8O3.Na/c1-2-3(5)4(6)7;/h3,5H,2H2,1H3,(H,6,7);/q;+1/p-1/t3-;/m1./s1

Upstream product

• 2013-26-5 2-oxobutyric acid, sodium salt 
• 3347-90-8 (2S)-2-hydroxybutanoic acid 

Downstream Products

• 132513-51-0 n-butyl (S)-2-hydroxybutanoate 

Relevant articles and documents

Method for Improving Optical Purity of 2-Hydroxycarboxylic Acid or Derivative Thereof

To provide a method for improving optical purity of an optically active 2-hydroxycarboxylic acid or a derivative thereof, which is useful as a raw material in the manufacture of medicines, agrochemicais, and industrial products. The method of the invention for improving purity of a hydroxycarboxylic acid of the following formula (1a) or (1b) or a derivative thereof includes the steps of reacting the hydroxycarboxylic acid of the following formula (1a) or (1b) with at least one optically inactive base selected from the group consisting of an alkali metal, alkoxide and a secondary amine in the presence of a solvent and, subsequently, performing recrystallization, to thereby form a hydroxycarboxylic acid salt of the following formula (IIIa) or (IIIb): wherein R1 represents a C1-8 alkyl group, and R2 represents an alkali metal or a secondary amine.

A new family of D-2-hydroxyacid dehydrogenases that comprises D-mandelate dehydrogenases and 2-ketopantoate reductases

The gene for the D-mandelate dehydrogenase (DManDH) of Enterococcus faecalis IAM10071 was isolated by means of an activity staining procedure and PCR and expressed in Escherichia coli cells. The recombinant enzyme exhibited high catalytic activity toward various 2-ketoacid substrates with bulky hydrophobic side chains, particularly C3-branched substrates such as benzoylformate and 2-ketoisovalerate, and strict coenzyme specificity for NADH and NAD+. It showed marked sequence similarity with known NADP-dependent 2-ketopantoate reductases (KPR). These results indicate that together with KPR, D-ManDH constitutes a new family of D-2-hydroxyacid dehydrogenases that act on C3-branched 2-ketoacid substrates with various specificities for coenzymes and substrates.