2013-26-5Relevant articles and documents
Process method for preparing sodium 2-ketobutyrate
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Paragraph 0065-0066; 0073-0086, (2020/06/02)
The invention discloses a process method for preparing sodium 2-ketobutyrate. The method comprises the following steps: S1, reacting diethyl methylmalonate or dimethyl methylmalonate used as a raw material with diethyl oxalate or dimethyl oxalate under the catalysis of a proper amount of an alkaline compound to obtain a 1-carbonyl propane-1,2,2-tricarboxylate intermediate; S2, reacting the 1-carbonyl propane-1,2,2-tricarboxylate intermediate obtained in step S1 with water under the catalysis of a proper amount of an acidic compound to obtain 2-ketobutyric acid; and S3, reacting the 2-ketobutyric acid obtained in step S2 with the alkaline compound to obtain the sodium 2-ketobutyrate. The method is reasonable in route design, safe, reliable, low in cost and capable of achieving quantitativeproduction.