- Synthesis and antimicrobial activity of triazolo quinazolinones
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The synthesis of some new fused triazoloquinazolinones from 3-amino-2-hydrazino-4 (3H)-quinazolinone is being reported along with their possible biological and pharmacological properties.
- Majahid, Abdul Khadar,Kalyane,Shivkumar,Shripad,Siddaram,Swamy
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p. 129 - 132
(2013/09/24)
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- Synthesis and Structure of Some Condensed Quinazolines
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Condensation of 2-hydrazino-4(3H)-quinazolinone (1) with bielectrophilic reagents gives the corresponding triazoloquinazolines 8, the structures of which were established by selective synthesis through deamination of their N-amino derivatives.The synthesis of methyl-substituted derivatives of these angular tricyclic systems and their linear isomers was also achieved starting with 3-methyl- and 1-methyl-2-hydrazinoquinazolinone.
- Badawy, Mohamed A.,Abdel-Hady, Sayed A.,Mahmoud, Ahmed H.,Ibrahim, Yehia A.
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p. 815 - 817
(2007/10/02)
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- Modified Procedure for the Preparation of 5-Nitro-2-furylmethylene Diacetate and Its Use in the Synthesis of Some Novel (5-Nitro-2-furyl)azomethines via 5-Nitro-2-furaldehyde
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A modified two-step procedure for the preparation of 5-nitro-2-furylmethylene diacetate (3) by nitration of 2-furaldehyde (1) or 2-furylmethylene diacetate (4) with acetyl nitrate via 2-acetoxy-5-nitro-2,5-dihydro-2-furylmethylene diacetate (2), or 1,1,5-triacetoxy-2-hydroxy-5-nitro-3-penten (5) and 1,1,5-triacetoxy-2-hydroxy-5-nitro-2,4-pentadiene (6), has been developed.Acid hydrolysis of 3 yields 5-nitro-2-furaldehyde (7) which is used in the carbonylamine condensation with various hydrazines (9-11, 14, 17, 19, 21, 24, 25, 28, 29, 32, 34, 36, 38, 39, 41 and 44-54) prepared by known methods, in order to obtain some novel potentially pharmaceutically active (5-nitro-2-furyl)azomethines.
- Vlaovic, Djordje,Milic, Bozidar Lj.,Mackenzie, Kenneth
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p. 1201 - 1218
(2007/10/02)
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- Synthesis of 4(3H)-Quinazolinones from Derivatives of Methyl 2-Isothiocyanatobenzoate
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Ethyl N-((2-methoxycarbonylphenyl)thiocarbamate (2), N-(2-ethoxycarbonylphenyl)-4-methoxythiobenzamide (3b), and 2-(4-methoxyphenyl)4H,-3,1-benzothiazin-4-one (4a), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2-substituted and 2,4-disubstituted 4(3H)-quinazolinones, as well as some tricyclic and tetracyclic products.
- Dean, William D.,Papadopoulos, Eleftherios P.
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p. 1117 - 1124
(2007/10/02)
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- Antihistaminic and bronchospasmolytic triazoloquinazolinones
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Novel triazoloquinazolinones of the formula STR1 wherein X is selected from the group consisting of hydrogen, halogen, --NO2, methyl, methoxy and --CF3, n is an integer from 2 to 5, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl and hydroxyalkyl of 1 to 5 carbon atoms and taken together with the nitrogen atom to which they are attached form a saturated heterocycle optionally containing another heteroatom and optionally substituted with at least one member of the group consisting of hydroxy, alkyl and hydroxyalkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an aliphatic carboxylic acid of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms and aryl optionally substituted with a halogen or --CF3 and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and their preparation.
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