19062-39-6

Usage

InChI:InChI=1/C8H9N5O/c9-12-8-11-6-4-2-1-3-5(6)7(14)13(8)10/h1-4H,9-10H2,(H,11,12)

Upstream product

• 59342-31-3 2-hydrazineylquinazolin-4(3H)-one 
• 18741-24-7 3-phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one 
• 73987-32-3 2-methylmercapto-3-phenyl-4(3H)-quinazolinone 
• 344312-25-0 2-ethoxythiocarbonylamino-benzoic acid methyl ester 
• 95241-43-3 3-amino-2-(phenylamino)-4(3H)-quinazolinone 
• 86662-57-9 3-ethyl-2-hydrazinylquinazolin-4(3H)-one 
• 85094-59-3 3-amino-2-ethoxy-4(3H)-quinazolinone 
• 96221-91-9 N-o-Carbomethoxyphenyl-N'-phenylthiourea 
• 134-20-3 2-carbomethoxyaniline 
• 16024-82-1 methyl 2-isothiocyanatobenzoate 
• 13906-08-6 3-ethyl-2-mercapto-4(3H)-quinazolinone 
• 731-52-2 2-hydrazino-3-phenyl-3H-quinazolin-4-one 
• 16951-33-0 3-amino-2-mercapto-3H-quinazolin-4-one 
• 261509-54-0 3-amino-2-methylsulfanyl-3H-quinazolin-4-one 

Downstream Products

• 123565-89-9 (Z)-2-[(3-Amino-4-oxo-3,4-dihydro-quinazolin-2-yl)-hydrazono]-4-(4-methoxy-phenyl)-but-3-enoic acid 
• 123593-02-2 (Z)-2-[(3-Amino-4-oxo-3,4-dihydro-quinazolin-2-yl)-hydrazono]-4-phenyl-but-3-enoic acid 
• 1363407-50-4 C₂₀H₁₃N₅O₂ 
• 1363407-51-5 C₂₂H₁₅N₅O₂ 
• 1363407-52-6 C₂₄H₂₀N₆O 
• 1363407-53-7 C₂₂H₁₄N₆O₃ 
• 1363407-54-8 benzaldehyde 
• 1363407-55-9 C₂₂H₁₄BrN₅O 
• 1363407-56-0 C₂₃H₁₇N₅O₂ 
• 1363407-57-1 C₂₂H₁₄FN₅O 
• 1363407-58-2 C₂₂H₁₄ClN₅O 
• 1363407-59-3 C₂₃H₁₇N₅O₂ 
• 440120-98-9 C₁₅H₁₁N₅O 
• 123566-00-7 10-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-3-[(E)-2-(4-methoxy-phenyl)-vinyl]-10H-1,2,4a,10-tetraaza-phenanthrene-4,9-dione 

Relevant academic research and scientific papers

Synthesis and antimicrobial activity of triazolo quinazolinones

The synthesis of some new fused triazoloquinazolinones from 3-amino-2-hydrazino-4 (3H)-quinazolinone is being reported along with their possible biological and pharmacological properties.

Synthesis and Structure of Some Condensed Quinazolines

Condensation of 2-hydrazino-4(3H)-quinazolinone (1) with bielectrophilic reagents gives the corresponding triazoloquinazolines 8, the structures of which were established by selective synthesis through deamination of their N-amino derivatives.The synthesis of methyl-substituted derivatives of these angular tricyclic systems and their linear isomers was also achieved starting with 3-methyl- and 1-methyl-2-hydrazinoquinazolinone.

Modified Procedure for the Preparation of 5-Nitro-2-furylmethylene Diacetate and Its Use in the Synthesis of Some Novel (5-Nitro-2-furyl)azomethines via 5-Nitro-2-furaldehyde

A modified two-step procedure for the preparation of 5-nitro-2-furylmethylene diacetate (3) by nitration of 2-furaldehyde (1) or 2-furylmethylene diacetate (4) with acetyl nitrate via 2-acetoxy-5-nitro-2,5-dihydro-2-furylmethylene diacetate (2), or 1,1,5-triacetoxy-2-hydroxy-5-nitro-3-penten (5) and 1,1,5-triacetoxy-2-hydroxy-5-nitro-2,4-pentadiene (6), has been developed.Acid hydrolysis of 3 yields 5-nitro-2-furaldehyde (7) which is used in the carbonylamine condensation with various hydrazines (9-11, 14, 17, 19, 21, 24, 25, 28, 29, 32, 34, 36, 38, 39, 41 and 44-54) prepared by known methods, in order to obtain some novel potentially pharmaceutically active (5-nitro-2-furyl)azomethines.

Synthesis of 4(3H)-Quinazolinones from Derivatives of Methyl 2-Isothiocyanatobenzoate

Ethyl N-((2-methoxycarbonylphenyl)thiocarbamate (2), N-(2-ethoxycarbonylphenyl)-4-methoxythiobenzamide (3b), and 2-(4-methoxyphenyl)4H,-3,1-benzothiazin-4-one (4a), react with nucleophilic reagents containing at least one primary amino group to yield a variety of 2-substituted and 2,4-disubstituted 4(3H)-quinazolinones, as well as some tricyclic and tetracyclic products.

Antihistaminic and bronchospasmolytic triazoloquinazolinones

Novel triazoloquinazolinones of the formula STR1 wherein X is selected from the group consisting of hydrogen, halogen, --NO2, methyl, methoxy and --CF3, n is an integer from 2 to 5, R1 and R2 are individually selected from the group consisting of hydrogen and alkyl and hydroxyalkyl of 1 to 5 carbon atoms and taken together with the nitrogen atom to which they are attached form a saturated heterocycle optionally containing another heteroatom and optionally substituted with at least one member of the group consisting of hydroxy, alkyl and hydroxyalkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, acyl of an aliphatic carboxylic acid of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 6 carbon atoms and aryl optionally substituted with a halogen or --CF3 and their non-toxic, pharmaceutically acceptable acid addition salts having antihistaminic and bronchospasmolytic activity and their preparation.