- Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.
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[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.
- Kim,Bae,So,Yoo,Chang,Lee,Kang
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p. 2349 - 2351
(2007/10/03)
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- Synthesis of novel, optically active, heterocyclic amino alcohols through desymmetrization of a C2-symmetric cyclic sulfate
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A general and efficient method for the synthesis of optically active cis-4-amino-3-hydroxy-substituted heterocycles (1-4) has been developed through desymmetrization of a C2-symmetric cyclic sulfate chiron prepared from catalytic asymmetric dihydroxylation of 1,4-dichloro-trans-2-butene.
- Kim, B. Moon,Bae, Sung Jin,Seomoon, Gunn
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p. 6921 - 6922
(2007/10/03)
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- Catalytic asymmetric synthesis of new halogenated chiral synthons
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Two-step and practical asymmetric syntheses of enantiomerically pure 4-trifluoromethyl-2.2-dioxo-1,3,2-dioxathiolane and 4-trichloromethyl-2,2-dioxo-1,3,2-dioxathiolane (>98% ee) have been achieved. Catalytic asymmetric dihydroxylation (AD) of 3,3,3-trifl
- Vanhessche, Koen P. M.,Sharpless, K. Barry
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p. 517 - 522
(2007/10/03)
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