191399-17-4Relevant articles and documents
Friedel-Crafts Reactions of 2-Amino-4-(alkyl or aryl)oxazoles with Acid Chlorides and Acid Anhydrides: Synthesis of 5-Acyl-2-amino-4-alkyloxazoles
Mekonnen, Belew,Crank, George
, p. 567 - 572 (1997)
Acid chlorides and anhydrides react with 2-amino-4-alkyloxazoles in the presence of aluminum chloride to produce 5-acyl substituted 2-amino-4-alkyloxazoles in modest yields. However, in the absence of the Lewis acid reaction occurs at the amino group to give the corresponding amides. This provides a viable entry for functionalising and making carbon-carbon bond at C-5 of this heterocyclic system.
Imine derivatives as new potent and selective CB2 cannabinoid receptor agonists with an analgesic action
Ohta, Hiroshi,Ishizaka, Tomoko,Tatsuzuki, Makoto,Yoshinaga, Mitsukane,Iida, Izumi,Yamaguchi, Tomomi,Tomishima, Yasumitsu,Futaki, Nobuko,Toda, Yoshihisa,Saito, Shuji
, p. 1111 - 1124 (2008/09/17)
In this study, a novel series of CB2 receptor agonist imine derivatives, 1-6, was synthesized and evaluated for activity against the CB2 receptor. In a previous paper we reported the synthesis and SARs of thiazole derivative 1, a pot
THIAZOLE DERIVATIVES AND USE THEREOF
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Page/Page column 77; 78, (2008/06/13)
The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.