191602-54-7

Basic information

• Product Name: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE
• Synonyms: 4-AMINO-2-BROMO(TRIFLUOROMETHOXY)BENZENE;3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE;3-Bromo-4-(trifluoromethoxy)aniline 98%;3-Bromo-4-(trifluoromethoxy)aniline98%;3-Fluoro-4-(Trifluoromethoxy)aniline;1-Amino-3-bromo-4-(trifluoromethoxy)benzene;3-broMo-4-(trifluoroMethoxy)benzenaMine
• CAS NO: 191602-54-7
• Molecular Formula: C7H5BrF3NO
• Molecular Weight: 256.02
• EINECS: 242-872-7
• Product Categories: Fluorine series
• Mol File: 191602-54-7.mol

Chemical Properties

• Boiling Point: 236.6 °C at 760 mmHg
• Flash Point: 96.9 °C
• Appearance: /
• Density: 1.726 g/cm³
• Refractive Index: 1.5100-1.5140
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.67±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(191602-54-7)
• EPA Substance Registry System: 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE(191602-54-7)

Safety Data

• Hazard Codes: T,Xi
• Statements: 36/37/38-43-25
• Safety Statements: 26-36/37/39-45-36/37
• RIDADR: UN2810
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 191602-54-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE is used as a building block in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs with specific therapeutic properties. The presence of the bromine and trifluoromethoxy groups enhances the compound's reactivity, facilitating the creation of a diverse range of medicinal agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE is employed as a key intermediate in the production of agrochemicals, such as pesticides and herbicides. Its unique chemical structure allows for the development of effective compounds that can protect crops and enhance agricultural productivity.
Used in Dye Industry:
3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE is utilized as a precursor in the synthesis of dyes, where its specific properties contribute to the creation of dyes with unique color characteristics and improved performance in various applications, such as textiles, plastics, and printing inks.
Used in Specialty Chemicals Manufacturing:
As an intermediate in the production of specialty chemicals, 3-BROMO-4-(TRIFLUOROMETHOXY)ANILINE plays a crucial role in the development of advanced materials and compounds with specific applications in various industries, including coatings, adhesives, and sealants. Its unique reactivity and solubility properties enable the creation of high-performance specialty chemicals that meet the demands of specialized applications.

InChI:InChI=1/F6P.NO2/c1-7(2,3,4,5)6;2-1-3/q-1;+1

Upstream product

• 200958-40-3 2-bromo-4-nitro-1-(trifluoromethoxy)benzene 
• 461-82-5 4-(trifluoromethoxy)aniline 

Downstream Products

• 1427026-60-5 C₂₉H₂₈F₃N₇O₂ 
• 1427026-54-7 C₂₀H₂₁BrF₃N₃O₂ 
• 866633-25-2 2-bromo-4-fluoro-1-(trifluoromethoxy)benzene 
• 866633-26-3 [2-(trifluoromethoxy)-5-fluorophenyl]boronic acid 
• 1076245-71-0 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-1-methyl-1H-pyrazole-5-carboxamide 
• 1076245-69-6 N-{6-amino-5-[5-fluoro-2-(trifluoromethoxy)phenyl]pyrazin-2-yl}-3-methylisoxazole-4-carboxamide 
• 839715-02-5 [3-(2-methyl-2H-pyrazol-3-yl)-4-trifluoromethoxyphenyl]carbamic acid tert-butyl ester 
• 1049730-98-4 3-bromo-N,N-dimethyl-4-(trifluoromethoxy)aniline 

Relevant articles and documents

Utilization of a Hydrogen Source from Renewable Lignocellulosic Biomass for Hydrogenation of Nitroarenes

Exploring of hydrogen source from renewable biomass, such as glucose in alkaline solution, for hydrogenation reactions had been studied since 1860s. According to proposed pathway, only small part of hydrogen source in glucose was utilized. Herein, the utilization of a hydrogen source from renewable lignocellulosic biomass, one of the most abundant renewable sources in nature, for a hydrogenation reaction is described. The hydrogenation is demonstrated by reduction of nitroarenes to arylamines in up to 95 % yields. Mechanism studies suggest that the hydrogenation occurs via a hydrogen transformation pathway.

Preparation method of 2, 4-dicarbonitrile trifluoromethoxybenzene

The invention discloses an industrial preparation method of 2, 4-dicarbonitrile trifluoromethoxybenzene. According to the industrial preparation method of the 2, 4-dicarbonitrile trifluoromethoxybenzene, p-aminotrifluoromethoxybenzene serves as an initial

Highly selective transfer hydrogenation of functionalised nitroarenes using cobalt-based nanocatalysts

Anilines are important feedstock for the synthesis of a variety of chemicals such as dyes, pigments, pharmaceuticals and agrochemicals. The chemoselective catalytic reduction of nitro compounds represents the most important and prevalent process for the manufacture of functionalized anilines. Consequently, the development of selective catalysts for the reduction of nitro compounds in the presence of other reducible groups is a major challenge and is crucial. In this regard, herein we show that the cobalt oxide (Co3O4-NGr@C) based nano-materials, prepared by the pyrolysis of cobalt-phenanthroline complexes on carbon constitute highly selective catalysts for the transfer hydrogenation of nitroarenes to anilines using formic acid as a hydrogen source. Applying these catalysts, a series of structurally diverse and functionalized nitroarenes have been reduced to anilines with unprecedented chemo-selectivity tolerating halides, olefins, aldehyde, ketone, ester, amide and nitrile functionalities.

Nitrogen-doped graphene-activated iron-oxide-based nanocatalysts for selective transfer hydrogenation of nitroarenes

Nanoscaled iron oxides on carbon were modified with nitrogen-doped graphene (NGr) and found to be excellent catalysts for the chemoselective transfer hydrogenation of nitroarenes to anilines. Under standard reaction conditions, a variety of functionalized and structurally diverse anilines, which serve as key building blocks and central intermediates for fine and bulk chemicals, were synthesized in good to excellent yields.

Nanoscale Fe2O3-based catalysts for selective hydrogenation of nitroarenes to anilines

Production of anilines - key intermediates for the fine chemical, agrochemical, and pharmaceutical industries - relies on precious metal catalysts that selectively hydrogenate aryl nitro groups in the presence of other easily reducible functionalities. Herein, we report convenient and stable iron oxide (Fe2O3) - based catalysts as a more earth-abundant alternative for this transformation. Pyrolysis of iron-phenanthroline complexes on carbon furnishes a unique structure in which the active Fe2O 3 particles are surrounded by a nitrogen-doped carbon layer. Highly selective hydrogenation of numerous structurally diverse nitroarenes (more than 80 examples) proceeded in good to excellent yield under industrially viable conditions.