Asymmetric Hydrogenation of In Situ Generated Isochromenylium Intermediates by Copper/Ruthenium Tandem Catalysis
The first asymmetric hydrogenation of in situ generated isochromenylium derivatives is enabled by tandem catalysis with a binary system consisting of Cu(OTf)2 and a chiral cationic ruthenium–diamine complex. A range of chiral 1H-isochromenes were obtained in high yields with good to excellent enantioselectivity. These chiral 1H-isochromenes could be easily transformed into isochromanes, which represent an important structural motif in natural products and biologically active compounds. The chiral induction was rationalized by density functional theory calculations.
Water-soluble arene ruthenium complexes containing a trans-1,2- diaminocyclohexane ligand as enantioselective transfer hydrogenation catalysts in aqueous solution
The cationic chloro complexes [(arene)Ru(H2N∩NH 2)Cl]+ (1: arene = C6H6; 2: arene = p-MeC6H4iPr; 3: arene = C6Me6) have been synthesised from the correspond
Canivet, Jerome,Labat, Gael,Stoeckli-Evans, Helen,Suess-Fink, Georg
p. 4493 - 4500
(2007/10/03)
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