Catalytic asymmetric nitroaldol reaction of α,α-difluoro aldehydes mediated by rare earth-lithium-BINOL complexes
Rare earth-Li-BINOL complexes were used to catalyze nitroaldol reactions of α,α-difluoro aldehydes with nitromethane in a good enantioselective manner. The optical yields of nitroaldol 2a depend on the size of rare earth metals, and an Sm-Li-BINOL complex
Synthesis and biological evluation of a fluorinated analog of the β-adrenergic blocking agent, metoprolol
Both enantiomers of a difluorinated metoprolol analog (1) were synthesized in enantiomerically pure form and evaluated as β-adrenergic blocking agents.